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Drug-associated non-pyrogenic hyperthermia: a narrative review
Citation
Bongers, K and Salahudeen, MS and Peterson, GM, Drug-associated non-pyrogenic hyperthermia: a narrative review, European Journal of Clinical Pharmacology ISSN 0031-6970 (2019) [Refereed Article]
Copyright Statement
Copyright 2019 Springer-Verlag GmbH Germany, part of Springer Nature
DOI: doi:10.1007/s00228-019-02763-5
Abstract
Purpose: Hyperthermia occurs when heat accumulation surpasses the body’s ability for heat dissipation. Many drugs may affect thermoregulation. This narrative review aimed to provide an overview of the current literature concerning reports of drugassociated non-pyrogenic hyperthermia.
Methods: A comprehensive search was performed across 5 databases covering the period of inception to March 2019, for
publications that reported hyperthermia associated with drug use. Studies that reported potential drug association with hyperthermia due to altered thermoregulatory mechanisms were included. Case reports of less than 3 cases were excluded, as well as
hyperthermia due to other causes, such as hypersensitivity, malignant hyperthermia and neuroleptic malignant syndrome. The
primary outcomes of interest were hospitalisation and mortality.
Results: The literature search initially identified a total of 2609 records. Based on full-text analysis, 11 articles met the inclusion
criteria, of which there were 5 case-control studies, 2 case series and 4 retrospective analyses. Studies reported heat-related
hospitalisations or emergency department presentations associated with the use of psychotropics (antipsychotics, antidepressants
and anxiolytics), anticholinergics, antihistamines, diuretics, cardiovascular agents, non-steroidal anti-inflammatory drugs and
anticoagulants. Psychotropic drugs were reported to be associated with increased heat-related mortality, other than through
neuroleptic malignant syndrome, but findings varied among the studies.
Conclusion: Given the relative lack of publications, more research is necessary to study specific effects of drugs on body
temperature and the likelihood of inducing non-pyrogenic hyperthermia. In particular, psychotropics, anticholinergics, diuretics
and cardiovascular agents are of interest for future studies.
Item Details
Item Type: | Refereed Article |
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Keywords: | hyperthermia, non-pyrogenic, heat stroke, heat exhaustion, thermoregulation, drug-associated, adverse drug reactions, hospitalisation |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Pharmacology and pharmaceutical sciences |
Research Field: | Clinical pharmacy and pharmacy practice |
Objective Division: | Health |
Objective Group: | Public health (excl. specific population health) |
Objective Field: | Preventive medicine |
UTAS Author: | Bongers, K (Mr Koen Bongers) |
UTAS Author: | Salahudeen, MS (Dr Mohammed Salahudeen) |
UTAS Author: | Peterson, GM (Professor Gregory Peterson) |
ID Code: | 135492 |
Year Published: | 2019 |
Web of Science® Times Cited: | 2 |
Deposited By: | Pharmacy |
Deposited On: | 2019-10-27 |
Last Modified: | 2020-03-11 |
Downloads: | 0 |
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