eCite Digital Repository

Interhemispheric connectivity potentiates the basolateral amygdalae and regulates social interaction and memory

Citation

Huang, T-N and Hsu, T-T and Lin, M-H and Chuang, H-C and Hu, H-T and Sun, C-P and Tao, M-H and Lin, JY and Chuang, H-C and Sun, C-P and Tao, M-H and Lin, JY and Hsueh, Y-P, Interhemispheric connectivity potentiates the basolateral amygdalae and regulates social interaction and memory, Cell reports, 29, (1) pp. 34-48. ISSN 2211-1247 (2019) [Refereed Article]


Preview
PDF
7Mb
  

Copyright Statement

Copyright 2019 the authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/

DOI: doi:10.1016/j.celrep.2019.08.082

Abstract

Impaired interhemispheric connectivity is commonly found in various psychiatric disorders, although how interhemispheric connectivity regulates brain function remains elusive. Here, we use the mouse amygdala, a brain region that is critical for social interaction and fear memory, as a model to demonstrate that contralateral connectivity intensifies the synaptic response of basolateral amygdalae (BLA) and regulates amygdala-dependent behaviors. Retrograde tracing and c-FOS expression indicate that contralateral afferents widely innervate BLA non-randomly and that some BLA neurons innervate both contralateral BLA and the ipsilateral central amygdala (CeA). Our optogenetic and electrophysiological studies further suggest that contralateral BLA input results in the synaptic facilitation of BLA neurons, thereby intensifying the responses to cortical and thalamic stimulations. Finally, pharmacological inhibition and chemogenetic disconnection demonstrate that BLA contralateral facilitation is required for social interaction and memory. Our study suggests that interhemispheric connectivity potentiates the synaptic dynamics of BLA neurons and is critical for the full activation and functionality of amygdalae.

Item Details

Item Type:Refereed Article
Keywords:Neurocircuit, optogenetics, chemogenetics, electrophysiology
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
UTAS Author:Lin, JY (Dr John Lin)
UTAS Author:Lin, JY (Dr John Lin)
ID Code:135334
Year Published:2019
Funding Support:National Health and Medical Research Council (1103034)
Web of Science® Times Cited:2
Deposited By:Medicine
Deposited On:2019-10-14
Last Modified:2019-11-06
Downloads:4 View Download Statistics

Repository Staff Only: item control page