135334 - Interhemispheric Connectivity Potentiates the Basolateral Amygdalae.pdf (7.11 MB)
Interhemispheric connectivity potentiates the basolateral amygdalae and regulates social interaction and memory
journal contribution
posted on 2023-05-20, 07:40 authored by Huang, T-N, Hsu, T-T, Lin, M-H, Chuang, H-C, Hu, H-T, Sun, C-P, Tao, M-H, John LinJohn Lin, Hsueh, Y-PImpaired interhemispheric connectivity is commonly found in various psychiatric disorders, although how interhemispheric connectivity regulates brain function remains elusive. Here, we use the mouse amygdala, a brain region that is critical for social interaction and fear memory, as a model to demonstrate that contralateral connectivity intensifies the synaptic response of basolateral amygdalae (BLA) and regulates amygdala-dependent behaviors. Retrograde tracing and c-FOS expression indicate that contralateral afferents widely innervate BLA non-randomly and that some BLA neurons innervate both contralateral BLA and the ipsilateral central amygdala (CeA). Our optogenetic and electrophysiological studies further suggest that contralateral BLA input results in the synaptic facilitation of BLA neurons, thereby intensifying the responses to cortical and thalamic stimulations. Finally, pharmacological inhibition and chemogenetic disconnection demonstrate that BLA contralateral facilitation is required for social interaction and memory. Our study suggests that interhemispheric connectivity potentiates the synaptic dynamics of BLA neurons and is critical for the full activation and functionality of amygdalae.
Funding
National Health & Medical Research Council
History
Publication title
Cell reportsVolume
29Pagination
34-48ISSN
2211-1247Department/School
Tasmanian School of MedicinePublisher
Cell PressPlace of publication
United StatesRights statement
Copyright 2019 the authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/Repository Status
- Open