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135334 - Interhemispheric Connectivity Potentiates the Basolateral Amygdalae.pdf (7.11 MB)

Interhemispheric connectivity potentiates the basolateral amygdalae and regulates social interaction and memory

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posted on 2023-05-20, 07:40 authored by Huang, T-N, Hsu, T-T, Lin, M-H, Chuang, H-C, Hu, H-T, Sun, C-P, Tao, M-H, John LinJohn Lin, Hsueh, Y-P
Impaired interhemispheric connectivity is commonly found in various psychiatric disorders, although how interhemispheric connectivity regulates brain function remains elusive. Here, we use the mouse amygdala, a brain region that is critical for social interaction and fear memory, as a model to demonstrate that contralateral connectivity intensifies the synaptic response of basolateral amygdalae (BLA) and regulates amygdala-dependent behaviors. Retrograde tracing and c-FOS expression indicate that contralateral afferents widely innervate BLA non-randomly and that some BLA neurons innervate both contralateral BLA and the ipsilateral central amygdala (CeA). Our optogenetic and electrophysiological studies further suggest that contralateral BLA input results in the synaptic facilitation of BLA neurons, thereby intensifying the responses to cortical and thalamic stimulations. Finally, pharmacological inhibition and chemogenetic disconnection demonstrate that BLA contralateral facilitation is required for social interaction and memory. Our study suggests that interhemispheric connectivity potentiates the synaptic dynamics of BLA neurons and is critical for the full activation and functionality of amygdalae.

Funding

National Health & Medical Research Council

History

Publication title

Cell reports

Volume

29

Pagination

34-48

ISSN

2211-1247

Department/School

Tasmanian School of Medicine

Publisher

Cell Press

Place of publication

United States

Rights statement

Copyright 2019 the authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/

Repository Status

  • Open

Socio-economic Objectives

Expanding knowledge in the biological sciences; Expanding knowledge in the health sciences; Expanding knowledge in psychology

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