eCite Digital Repository

Serotonin improves high fat diet induced obesity in mice


Watanabe, H and Nakano, T and Saito, R and Akasaka, D and Saito, K and Ogasawara, H and Minashima, T and Miyazawa, K and Kanaya, T and Takakura, I and Inoue, N and Ikeda, I and Chen, X and Miyake, M and Kitazawa, H and Shirakawa, H and Sato, K and Tahara, K and Nagasawa, Y and Rose, MT and Ohwada, S and Watanabe, K and Aso, H, Serotonin improves high fat diet induced obesity in mice, PLoS ONE, 11, (1) Article e0147143. ISSN 1932-6203 (2016) [Refereed Article]


Copyright Statement

Copyright 2016 Watanabe et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.1371/journal.pone.0147143


There are two independent serotonin (5-HT) systems of organization: one in the central nervous system and the other in the periphery. 5-HT affects feeding behavior and obesity in the central nervous system. On the other hand, peripheral 5-HT also may play an important role in obesity, as it has been reported that 5-HT regulates glucose and lipid metabolism. Here we show that the intraperitoneal injection of 5-HT to mice inhibits weight gain, hyperglycemia and insulin resistance and completely prevented the enlargement of intra-abdominal adipocytes without having any effect on food intake when on a high fat diet, but not on a chow diet. 5-HT increased energy expenditure, O2 consumption and CO2 production. This novel metabolic effect of peripheral 5-HT is critically related to a shift in the profile of muscle fiber type from fast/glycolytic to slow/oxidative in soleus muscle. Additionally, 5-HT dramatically induced an increase in the mRNA expression of peroxisome proliferator-activated receptor coactivator 1α (PGC-1α)-b and PGC-1α-c in soleus muscle. The elevation of these gene mRNA expressions by 5-HT injection was inhibited by treatment with 5-HT receptor (5HTR) 2A or 7 antagonists. Our results demonstrate that peripheral 5-HT may play an important role in the relief of obesity and other metabolic disorders by accelerating energy consumption in skeletal muscle.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Endocrinology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Rose, MT (Dr Michael Rose)
ID Code:135246
Year Published:2016
Web of Science® Times Cited:31
Deposited By:Office of the Tasmanian Institute of Agriculture
Deposited On:2019-10-08
Last Modified:2019-11-13
Downloads:20 View Download Statistics

Repository Staff Only: item control page