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Serotonin improves high fat diet induced obesity in mice
Citation
Watanabe, H and Nakano, T and Saito, R and Akasaka, D and Saito, K and Ogasawara, H and Minashima, T and Miyazawa, K and Kanaya, T and Takakura, I and Inoue, N and Ikeda, I and Chen, X and Miyake, M and Kitazawa, H and Shirakawa, H and Sato, K and Tahara, K and Nagasawa, Y and Rose, MT and Ohwada, S and Watanabe, K and Aso, H, Serotonin improves high fat diet induced obesity in mice, PLoS ONE, 11, (1) Article e0147143. ISSN 1932-6203 (2016) [Refereed Article]
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Copyright Statement
Copyright 2016 Watanabe et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
DOI: doi:10.1371/journal.pone.0147143
Abstract
There are two independent serotonin (5-HT) systems of organization: one in the central nervous system and the other in the periphery. 5-HT affects feeding behavior and obesity in the central nervous system. On the other hand, peripheral 5-HT also may play an important role in obesity, as it has been reported that 5-HT regulates glucose and lipid metabolism. Here we show that the intraperitoneal injection of 5-HT to mice inhibits weight gain, hyperglycemia and insulin resistance and completely prevented the enlargement of intra-abdominal adipocytes without having any effect on food intake when on a high fat diet, but not on a chow diet. 5-HT increased energy expenditure, O2 consumption and CO2 production. This novel metabolic effect of peripheral 5-HT is critically related to a shift in the profile of muscle fiber type from fast/glycolytic to slow/oxidative in soleus muscle. Additionally, 5-HT dramatically induced an increase in the mRNA expression of peroxisome proliferator-activated receptor coactivator 1α (PGC-1α)-b and PGC-1α-c in soleus muscle. The elevation of these gene mRNA expressions by 5-HT injection was inhibited by treatment with 5-HT receptor (5HTR) 2A or 7 antagonists. Our results demonstrate that peripheral 5-HT may play an important role in the relief of obesity and other metabolic disorders by accelerating energy consumption in skeletal muscle.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Endocrinology |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the biological sciences |
| UTAS Author: | Rose, MT (Dr Michael Rose) |
| ID Code: | 135246 |
| Year Published: | 2016 |
| Web of Science® Times Cited: | 26 |
| Deposited By: | Office of the Tasmanian Institute of Agriculture |
| Deposited On: | 2019-10-08 |
| Last Modified: | 2019-11-13 |
| Downloads: | 15 View Download Statistics |
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