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Gene polymorphisms and circulating levels of the TNF-alpha are associated with ischemic stroke: a meta-analysis based on 19,873 individuals
Citation
Wu, JC and Zhang, X and Wang, JH and Liu, QW and Wang, XQ and Wu, ZQ and Wang, J and Zhang, C and Qun, S, Gene polymorphisms and circulating levels of the TNF-alpha are associated with ischemic stroke: a meta-analysis based on 19,873 individuals, International Immunopharmacology, 75 Article 105827. ISSN 1567-5769 (2019) [Refereed Article]
Copyright Statement
Copyright 2019 Elsevier B.V.
DOI: doi:10.1016/j.intimp.2019.105827
Abstract
Methods: Relevant publications were retrieved by searching databases. Odds ratios (ORs) and standard mean differences (SMDs) with 95% confidence intervals (95% CIs) were used to assess the association of the TNF-α gene and cytokine with IS, respectively. The Cochrane Q test and I2 statistic were used to test heterogeneity. Subgroup analysis and publication bias were performed.
Results: 25 and 9 articles examined the association of polymorphisms and levels of the TNF-α with IS risk, respectively. Rs1800629 polymorphism was associated with IS susceptibility (OR (95% CI) =0.82 (0.72, 0.95)), especially in Asians (OR (95% CI) =0.75 (0.63, 0.89)); and rs1800610 was associated with IS susceptibility in Asians patients (OR (95% CI) =1.54 (1.31, 1.80)). While rs361525, rs1799964 and rs1799724 polymorphisms were not associated with IS susceptibility. The TNF-α level was elevated in IS patients (SMD (95% CI) =0.65 (0.29, 1.01)) including Asians (SMD (95% CI) =1.26 (0.49, 2.03)) and Caucasians (SMD (95% CI) =0.26 (0.03, 0.49)). In addition, increased level occurred in patients' serum (SMD (95% CI) =0.54 (0.08, 1.01)).
Conclusions: Rs1800629 and rs1800610 polymorphisms were elucidated to be a protective factor for IS (especially in Asians) and a risk factor for Asians patients, respectively. The TNF-α level was elevated in IS, indicating that TNF-α plays an important role in the pathogenesis of IS and is a promising therapeutic target for IS.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | cytokine, gene, ischemic stroke, polymorphism, stroke, TNF-α |
| Research Division: | Biological Sciences |
| Research Group: | Genetics |
| Research Field: | Genetic Immunology |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Inherited Diseases (incl. Gene Therapy) |
| UTAS Author: | Zhang, X (Mr Xu Zhang) |
| ID Code: | 135136 |
| Year Published: | 2019 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2019-10-02 |
| Last Modified: | 2019-11-14 |
| Downloads: | 0 |
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