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High pyridine generation in ceftazidime-icodextrin admixtures used to treat peritoneal dialysis-associated peritonitis


Kaur, H and Harmanjeet, H and Wanandy, T and Castelino, RL and Sud, K and Jose, MD and Peterson, GM and Patel, RP, High pyridine generation in ceftazidime-icodextrin admixtures used to treat peritoneal dialysis-associated peritonitis, Clinical Therapeutics, 41, (11) pp. 2446-2451. ISSN 0149-2918 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 Elsevier Inc.

DOI: doi:10.1016/j.clinthera.2019.08.021


Purpose: To investigate the amount of pyridine generated from degradation of ceftazidime in icodextrin peritoneal dialysis (PD) solutions.

Methods: PD solutions that contained 1 and 1.5 g of ceftazidime were stored at 25 C for 12 hours and then at 37 C for 14 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentrations of ceftazidime and pyridine.

Findings: The amount of pyridine generated was >225% and 400% of its maximum recommended daily exposure in the 1- and 1.5-g ceftazidime-PD admixtures, respectively.

Implications: Until these results are confirmed with appropriate in vivo studies, intermittent intraperitoneal dosing of ceftazidime admixed with icodextrin should be used with caution and appropriate clinical monitoring or a suitable alternative antibiotic should be used.

Item Details

Item Type:Refereed Article
Keywords:ceftazidime, peritoneal dialysis, peritonitis, pyridine, stability, toxicity
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Kaur, H (Mrs Harpreet Kaur)
UTAS Author:Harmanjeet, H (Mr Harmanjeet Harmanjeet)
UTAS Author:Wanandy, T (Mr Troy Wanandy)
UTAS Author:Castelino, RL (Dr Ronald Castelino)
UTAS Author:Jose, MD (Professor Matthew Jose)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Patel, RP (Dr Rahul Patel)
ID Code:135105
Year Published:2019
Web of Science® Times Cited:1
Deposited By:Pharmacy
Deposited On:2019-09-30
Last Modified:2020-02-25

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