Kaur, H and Harmanjeet, H and Wanandy, T and Castelino, RL and Sud, K and Jose, MD and Peterson, GM and Patel, RP, High pyridine generation in ceftazidime-icodextrin admixtures used to treat peritoneal dialysis-associated peritonitis, Clinical Therapeutics, 41, (11) pp. 2446-2451. ISSN 0149-2918 (2019) [Refereed Article]
Copyright 2019 Elsevier Inc.
Purpose: To investigate the amount of pyridine generated from degradation of ceftazidime in icodextrin peritoneal dialysis (PD) solutions.
Methods: PD solutions that contained 1 and 1.5 g of ceftazidime were stored at 25 °C for 12 hours and then at 37 °C for 14 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentrations of ceftazidime and pyridine.
Findings: The amount of pyridine generated was >225% and 400% of its maximum recommended daily exposure in the 1- and 1.5-g ceftazidime-PD admixtures, respectively.
Implications: Until these results are confirmed with appropriate in vivo studies, intermittent intraperitoneal dosing of ceftazidime admixed with icodextrin should be used with caution and appropriate clinical monitoring or a suitable alternative antibiotic should be used.
|Item Type:||Refereed Article|
|Keywords:||ceftazidime, peritoneal dialysis, peritonitis, pyridine, stability, toxicity|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Pharmacology and pharmaceutical sciences|
|Research Field:||Pharmaceutical sciences|
|Objective Group:||Other health|
|Objective Field:||Other health not elsewhere classified|
|UTAS Author:||Kaur, H (Mrs Harpreet Kaur)|
|UTAS Author:||Harmanjeet, H (Mr Harmanjeet Harmanjeet)|
|UTAS Author:||Wanandy, T (Mr Troy Wanandy)|
|UTAS Author:||Castelino, RL (Dr Ronald Castelino)|
|UTAS Author:||Jose, MD (Professor Matthew Jose)|
|UTAS Author:||Peterson, GM (Professor Gregory Peterson)|
|UTAS Author:||Patel, RP (Dr Rahul Patel)|
|Web of Science® Times Cited:||1|
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