Piloting a clinical laboratory method to evaluate the influence of potential modified risk tobacco products on smokers' quit-related motivation, choice, and behavior
Ozga-Hess, JE and Felicione, NJ and Ferguson, SG and Dino, G and Elswick, D and Whitworth, C and Turiano, N and Blank, MD, Piloting a clinical laboratory method to evaluate the influence of potential modified risk tobacco products on smokers' quit-related motivation, choice, and behavior, Addictive Behaviors, 99 Article 106105. ISSN 0306-4603 (2019) [Refereed Article]
Research methods are needed that can predict whether the availability of potential modified risk tobacco products (MRTPs) may influence smokers' quit-related motivation, choice, and behavior. This pilot study assessed
the primary outcomes of feasibility and adherence to address this need using an electronic cigarette (ECIG) as a
model MRTP. Cigarette smokers were randomly assigned to use only their own brand of cigarettes (OB-only) or a
second-generation ECIG (18 ng/ml nicotine) plus their OB cigarettes (ECIG+OB) ad libitum for four weeks.
Participants logged products using a mobile device, collected used cigarette filters, and provided saliva samples
every day for analysis of cotinine. They returned to the lab once per week to provide a breath sample and accept
or decline a choice to quit all tobacco products (i.e., cigarettes and/or ECIGs). They also returned for a onemonth follow-up visit. Of those participants randomized (n = 60), 56.7% completed the 4-week intervention and
40.0% completed the follow-up visit. The primary reason for withdrawal was poor adherence with mobile device
use. Comparable numbers of participants in each group chose to make a quit attempt, although more OB-only
participants chose to quit during the first two weeks and more ECIG+OB participants during the last two weeks.
With protocol modifications to reduce participation burden, the current method might ultimately be used by
regulators to predict how smokers' quit-related motivation, choice, and behavior are influenced by current and