Nguyen, MT and Saffery, R and Burgner, D and Lycett, K and Vryer, R and Grobler, A and Dwyer, T and Ranganathan, S and Wake, M, Telomere length and lung function in a population-based cohort of children and mid-life adults, Pediatric Pulmonology pp. 1-9. ISSN 8755-6863 (2019) [Refereed Article]
Copyright 2019 Wiley Periodicals, Inc.
Methods: Data were drawn from a population-based cross-sectional study of 11 to 12 year-olds and mid-life adults. Lung function was assessed by spirometric FEV1, FVC, FEV1 /FVC ratio, and MMEF25-75. Telomere length was measured by quantitative polymerase chain reaction from blood and expressed as the amount of telomeric genomic DNA to the beta-globin gene (T/S ratio). Associations of telomere length with spirometric parameters were tested by linear and logistic regression models, adjusting for potential confounders of sex, age, body mass index, socioeconomic position, physical activity, inflammation, asthma, pubertal status, and smoking.
Results: Mean T/S ratio was 1.09 (n = 1206; SD 0.55) in children and 0.81 (n = 1343; SD 0.38) in adults. In adults, for every additional unit in T/S ratio, FEV1/FVC and MMEF25-75 z-scores were higher (β 0.21 [95% confidence interval, CI; 0.06-0.36] and 0.23 [95% CI; 0.08-0.38], respectively), and the likelihood of being in the lowest quartile for FEV1/FVC and MMEF25-75 z-scores was lower (odds ratios 0.59 [95% CI, 0.39-0.89] and 0.64 [95% CI, 0.41-0.99], respectively). No evidence of association was seen for adult FEV1 or FVC, or any childhood spirometric index after adjustments.
Conclusion: Shorter telomere length showed moderate associations with poorer airflow parameters, but not vital capacity (lung volume) in mid-life adults. However, there was no convincing evidence of associations in children.
|Item Type:||Refereed Article|
|Keywords:||aging, cell senescence, life course, national cohort, spirometry|
|Research Division:||Biomedical and Clinical Sciences|
|Research Field:||Paediatrics not elsewhere classified|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Dwyer, T (Professor Terry Dwyer)|
|Web of Science® Times Cited:||1|
|Deposited By:||Menzies Institute for Medical Research|
Repository Staff Only: item control page