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Emerging roles for G-protein coupled receptors in development and activation of macrophages


Wang, X and Iyer, A and Lyons, AB and Korner, H and Wei, W, Emerging roles for G-protein coupled receptors in development and activation of macrophages, Frontiers in Immunology, 10 Article 2031. ISSN 1664-3224 (2019) [Refereed Article]


Copyright Statement

Copyright 2019 Wang, Iyer, Lyons, Korner and Wei. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3389/fimmu.2019.02031


Macrophages have emerged as a key component of the innate immune system that emigrates to peripheral tissues during gestation and in the adult organism. Their complex pathway to maturity, their unique plasticity and their various roles as effector and regulatory cells during an immune response have been the focus of intense research. A class of surface molecules, the G-Protein coupled receptors (GPCRs) play important roles in many immune processes. They have drawn attention in regard to these functions and the potential for therapeutic targets that can modulate the response of immune cells in pathologies such as diabetes, atherosclerosis, and chronic inflammatory diseases. Of the more than 800 GPCRs identified, ∼100 are currently targeted with drugs which have had their activity investigated in vivo. Macrophages express a number of GPCRs which have central roles during cell differentiation and in the regulation of their functions. While some macrophage GPCRs such as chemokine receptors have been studied in great detail, the roles of other receptors of this large family are still not well understood. This review summarizes new insights into macrophage biology, differences of human, and mouse macrophages and gives details of some of the GPCRs expressed by this cell type.

Item Details

Item Type:Refereed Article
Keywords:G-protein coupled receptors, macrophages, differentiation, polarization, innate immunity
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Cellular immunology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Lyons, AB (Associate Professor Bruce Lyons)
UTAS Author:Korner, H (Professor Heinrich Korner)
ID Code:134989
Year Published:2019
Web of Science® Times Cited:14
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-09-18
Last Modified:2022-08-25
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