eCite Digital Repository
Plasma lipoprotein-associated phospholipase A2 and superoxide dismutase are independent predicators of cognitive impairment in cerebral small vessel disease patients: diagnosis and assessment
Citation
Zhu, S and Wei, X and Yang, X and Huang, Z and Chang, Z and Xie, F and Yang, Q and Ding, C and Xiang, W and Yang, H and Xia, Y and Feng, Z-P and Sun, H-S and Yenari, MA and Shi, L and Mok, VCT and Wang, Q, Plasma lipoprotein-associated phospholipase A2 and superoxide dismutase are independent predicators of cognitive impairment in cerebral small vessel disease patients: diagnosis and assessment, Aging and Disease, 10, (4) pp. 834-846. ISSN 2152-5250 (2019) [Refereed Article]
 | PDF Pending copyright assessment - Request a copy 1Mb |
DOI: doi:10.14336/AD.2019.0304
Abstract
Lipoprotein-associated phospholipase A2 (Lp-PLA2) and superoxide dismutase (SOD) are linked to regulating vascular/neuro-inflammation and stroke. Using a retrospective design, we investigated whether circulating Lp-PLA2 and SOD in cerebral small vessel disease (CSVD) patients were associated with cognitive impairment. Eighty-seven CSVD patients were recruited. Plasma Lp-PLA2 and SOD were determined, and cognitive status was measured by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). The severity of white matter hypoerintensities (WMHs) in CSVD patients was rated according to Fazekas scales, and Lp-PLA2/SOD levels and MMSE/MoCA were compared. Multiple linear regressions were used to evaluate the relationship between Lp-PLA2 and SOD and the cognitive impairment. Ordinal logistic regression and generalized linear models (OLRGLMs) were applied to confirm whether Lp-PLA2 and SOD are independent risk factors for cognitive impairment in CVSD. Lp-PLA2 and SOD with mild or severe cognitive impairment were lower than those with normal congnition. Lp-PLA2 and SOD in CSVD patients with severe WMHs were significantly lower than those with mild or moderate WMH lesions. We noted positive linear associations of Lp-PLA and SOD with cognitive impairment in CSVD, independent of LDL-C. OLRGLMs confirmed that Lp-PLA2 and SOD were independent risk factors of cognitive impairment in CSVD. Lp-PLA2 and SOD are independently associated with cognitive impairment and WMH lesion, and may be useful for the rapid evaluation of cognitive impairment in CSVD. Lp-PLA2/SOD are modifiable factors that may be considered as therapeutic targets for preventing cognitive impairment in CSVD.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Lp-PLA2, cerebral small vessel disease, cognition, superoxide dismutase |
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Cellular Nervous System |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Neurodegenerative Disorders Related to Ageing |
| UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
| ID Code: | 134915 |
| Year Published: | 2019 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2019-09-12 |
| Last Modified: | 2019-09-17 |
| Downloads: | 0 |
Repository Staff Only: item control page