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Effect of pharmacist-led medication review on medication appropriateness in older adults with chronic kidney disease


Tesfaye, WH and Wimmer, BC and Peterson, GM and Castelino, RL and Jose, M and McKercher, C and Zaidi, STR, Effect of pharmacist-led medication review on medication appropriateness in older adults with chronic kidney disease, Journal of Pharmacy Practice and Research pp. 1-6. ISSN 1445-937X (2019) [Refereed Article]

Copyright Statement

2019 The Society of Hospital Pharmacists of Australia

DOI: doi:10.1002/jppr.1539


This study evaluated the effect of pharmacist-led review on medication appropriateness in 204 older patients with chronic kidney disease (CKD) admitted to an Australian hospital. Medication appropriateness was evaluated using the Medication Appropriateness Index (MAI) prior to medication review, after review (assuming all recommendations were accepted by physicians) and after outcome (acceptance/non-acceptance) of recommendations. Overall, 95 patients (46%) received a medication review by pharmacists. The median (interquartile range) MAI score decreased significantly from a baseline of 7 (312) to 5 (210) after medication review (p < 0.001) and to 6 (210) after the outcome of recommendations (p < 0.01). The MAI score also decreased in patients with no medication review by a pharmacist from 6 (311) at admission to 5 (29) at discharge (p < 0.001). MAI scores declined markedly in people with all pharmacist-conducted medication review recommendations accepted (from 7 to 3; p < 0.05). Reassuringly, hospitalisation alone improved medication appropriateness. However, pharmacist-led medication review can further optimise medication appropriateness in older CKD patients, particularly when the recommendations are implemented.

Item Details

Item Type:Refereed Article
Keywords:chronic kidney disease, medication appropriateness, pharmacist, elderly
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacy and pharmacy practice
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Tesfaye, WH (Mr Wubshet Tesfaye)
UTAS Author:Wimmer, BC (Dr Barbara Wimmer)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Jose, M (Professor Matthew Jose)
UTAS Author:McKercher, C (Dr Charlotte McKercher)
UTAS Author:Zaidi, STR (Dr Tabish Razi Zaidi)
ID Code:134910
Year Published:2019
Deposited By:Pharmacy
Deposited On:2019-09-12
Last Modified:2019-10-21

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