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Dietary patterns and β-amyloid deposition in aging Australian women

Citation

Hill, E and Clifton, P and Goodwill, AM and Dennerstein, L and Campbell, S and Szoeke, C, Dietary patterns and β-amyloid deposition in aging Australian women, Alzheimer's & Dementia, 4 pp. 535-541. ISSN 1552-5260 (2018) [Refereed Article]


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Copyright Statement

Copyright 2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

DOI: doi:10.1016/j.trci.2018.09.007

Abstract

Introduction: Evidence indicates that associations between diet and Alzheimer's disease may occur through biomarker pathways such as amyloid-β (Aβ); however, few studies have investigated dietary/Aβ relationships, and no study has investigated this relationship in women.

Methods: Dietary patterns were extrapolated for 115 participants from the Women's Health Aging Project. Aβ deposition was measured via in vivo F-18 florbetaben positron emission tomography scanning.

Results: Participants were, on average, aged 70 years (±2.63 SD), had 13 years of education (±3.57 SD), a BMI of 28 kg/m2 (±5.46 SD), and a daily energy intake of 5161 kJ (±1679.03 SD). Four dietary patterns were identified: high fat, Mediterranean, junk food, and low fat. Adherence to the junk food diet was a significant predictor of Aβ deposition (β = .10, P = .03).

Discussion: This study highlights the potential of diet to influence neurodegenerative disease and as a potential modifiable lifestyle risk factor for Alzheimer's disease.

Item Details

Item Type:Refereed Article
Keywords:Alzheimer's disease, biomarkers, diet, dietary pattern, factor analysis, neuropathology, nutrition, women, β-amyloid protein
Research Division:Biomedical and Clinical Sciences
Research Group:Nutrition and dietetics
Research Field:Nutrition and dietetics not elsewhere classified
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Nutrition
UTAS Author:Hill, E (Dr Edward Hill)
ID Code:134903
Year Published:2018
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-09-11
Last Modified:2019-10-02
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