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Diet and biomarkers of Alzheimer's disease: a systematic review and meta-analysis
Citation
Hill, E and Goodwill, AM and Gorelik, A and Szoeke, C, Diet and biomarkers of Alzheimer's disease: a systematic review and meta-analysis, Neurobiology of Aging, 76 pp. 45-52. ISSN 0197-4580 (2019) [Refereed Article]
Copyright Statement
Copyright 2019 Elsevier Inc. All rights reserved.
DOI: doi:10.1016/j.neurobiolaging.2018.12.008
Abstract
Alzheimer's disease (AD) risk increases with age and lacks efficacious pharmacological options. Summaries of the existing evidence reveal an association between Mediterranean-style diet adherence and reduced AD incidence; however, no review has investigated this relationship with respect to the hallmark AD biomarkers (tau and beta-amyloid) that manifest decades before clinical symptomatology. MEDLINE, PubMed, PsycINFO, Google Scholar, and SCOPUS databases were systematically searched to identify peer-reviewed articles investigating diet and AD biomarkers in the last 2 decades. Two thousand seven hundred twenty-six records were extracted, quality assessed, and double-blind screened by 2 authors. Fifteen studies met the inclusion criteria and 13 studies found a significant relationship. Of these, 4 studies found a high-glycemic load was related to an increase in AD biomarker burden; 6 found adherence to a Mediterranean or "AD-protective" dietary pattern conferred a reduction in AD biomarker burden. Meta-analysis revealed a small but significant effect of diet on AD biomarkers (β = 0.11 [95% CI 0.04-0.17], p = 0.002). This systematic review supports the notion that diet and nutrition display potential for nonpharmacological AD prevention.
Item Details
Item Type: | Refereed Article |
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Keywords: | Alzheimer's disease, beta-amyloid, biomarkers, diet, nutrition, Tau |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Nutrition and dietetics |
Research Field: | Nutrition and dietetics not elsewhere classified |
Objective Division: | Health |
Objective Group: | Public health (excl. specific population health) |
Objective Field: | Nutrition |
UTAS Author: | Hill, E (Dr Edward Hill) |
ID Code: | 134900 |
Year Published: | 2019 |
Web of Science® Times Cited: | 36 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2019-09-11 |
Last Modified: | 2019-10-16 |
Downloads: | 0 |
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