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Diet and biomarkers of Alzheimer's disease: a systematic review and meta-analysis

Citation

Hill, E and Goodwill, AM and Gorelik, A and Szoeke, C, Diet and biomarkers of Alzheimer's disease: a systematic review and meta-analysis, Neurobiology of Aging, 76 pp. 45-52. ISSN 0197-4580 (2019) [Refereed Article]


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DOI: doi:10.1016/j.neurobiolaging.2018.12.008

Abstract

Alzheimer's disease (AD) risk increases with age and lacks efficacious pharmacological options. Summaries of the existing evidence reveal an association between Mediterranean-style diet adherence and reduced AD incidence; however, no review has investigated this relationship with respect to the hallmark AD biomarkers (tau and beta-amyloid) that manifest decades before clinical symptomatology. MEDLINE, PubMed, PsycINFO, Google Scholar, and SCOPUS databases were systematically searched to identify peer-reviewed articles investigating diet and AD biomarkers in the last 2 decades. Two thousand seven hundred twenty-six records were extracted, quality assessed, and double-blind screened by 2 authors. Fifteen studies met the inclusion criteria and 13 studies found a significant relationship. Of these, 4 studies found a high-glycemic load was related to an increase in AD biomarker burden; 6 found adherence to a Mediterranean or "AD-protective" dietary pattern conferred a reduction in AD biomarker burden. Meta-analysis revealed a small but significant effect of diet on AD biomarkers (β = 0.11 [95% CI 0.04-0.17], p = 0.002). This systematic review supports the notion that diet and nutrition display potential for nonpharmacological AD prevention.

Item Details

Item Type:Refereed Article
Keywords:Alzheimer's disease, beta-amyloid, biomarkers, diet, nutrition, Tau
Research Division:Medical and Health Sciences
Research Group:Nutrition and Dietetics
Research Field:Nutrition and Dietetics not elsewhere classified
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Nutrition
UTAS Author:Hill, E (Mr Edward Hill)
ID Code:134900
Year Published:2019
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-09-11
Last Modified:2019-09-11
Downloads:0

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