Shang, X and Peng, W and Hill, E and Szoeke, C and He, M and Zhang, L, Incidence of medication-treated depression and anxiety associated with long-term cancer, cardiovascular disease, diabetes and osteoarthritis in community-dwelling women and men, EClinicalMedicine pp. 1-9. ISSN 2589-5370 (2019) [Refereed Article]
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Methods: We included 115,094 participants (54.3% women) aged 45–64 years from the 45 and Up Study who were free of depression, anxiety, and Parkinson's disease at baseline (2006–2009). The incidence of depression and anxiety was identified using claim databases during follow-up until December 2016. Cox regression models were used to examine the association of cancer, cardiovascular disease, diabetes, and osteoarthritis at baseline with incident depression and anxiety.
Findings: During a mean eight-year follow-up (958,785 person-year), the cumulative incidence of depression and anxiety was 12.5% and 5.9% in the healthy population. Hazard ratios ([HRs] (95% CI) versus healthy population) for incident depression associated with long-term cancer, cardiovascular disease, diabetes, and osteoarthritis were 1.19 (95% CI: 1.13–1.25), 1.08 (1.00–1.16)), 1.18 (1.09–1.28), and 1.94 (1.80–2.10), respectively. The corresponding HRs (95% CIs) for incident anxiety were 1.11 (1.03–1.20), 1.26 (1.14–1.39), 1.10 (0.98–1.24), and 2.01 (1.80–2.23), respectively. The positive association between cancer and incident depression was more evident in men (HR (95% CI): 1.24 (1.13–1.35) than in women (1.14 (1.07–1.21). Long-term diabetes was an independent risk factor for incident anxiety in men (1.21 (1.02–1.44) but not in women (1.09 (0.93–1.28)).
Interpretation: Long-term osteoarthritis, cardiovascular disease, and cancer were independent risk factors for incident depression and anxiety in both genders with osteoarthritis having the highest relative risk.
|Item Type:||Refereed Article|
|Keywords:||cardiovascular disease, cancer, diabetes, osteoarthritis, depression, anxiety|
|Research Division:||Health Sciences|
|Research Group:||Health services and systems|
|Research Field:||Health services and systems not elsewhere classified|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Mental health|
|UTAS Author:||Hill, E (Dr Edward Hill)|
|Web of Science® Times Cited:||2|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||7 View Download Statistics|
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