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Incidence of medication-treated depression and anxiety associated with long-term cancer, cardiovascular disease, diabetes and osteoarthritis in community-dwelling women and men

Citation

Shang, X and Peng, W and Hill, E and Szoeke, C and He, M and Zhang, L, Incidence of medication-treated depression and anxiety associated with long-term cancer, cardiovascular disease, diabetes and osteoarthritis in community-dwelling women and men, EClinicalMedicine pp. 1-9. ISSN 2589-5370 (2019) [Refereed Article]


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DOI: doi:10.1016/j.eclinm.2019.08.010

Abstract

Background: Long-termcancer, cardiovascular disease, diabetes and osteoarthritismay increase the risk ofmental disorders, but which was more harmful and whether the associations differed between genders is unclear.

Methods: We included 115,094 participants (54.3% women) aged 4564 years from the 45 and Up Study who were free of depression, anxiety, and Parkinson's disease at baseline (20062009). The incidence of depression and anxiety was identified using claim databases during follow-up until December 2016. Cox regression models were used to examine the association of cancer, cardiovascular disease, diabetes, and osteoarthritis at baseline with incident depression and anxiety.

Findings: During a mean eight-year follow-up (958,785 person-year), the cumulative incidence of depression and anxiety was 12.5% and 5.9% in the healthy population. Hazard ratios ([HRs] (95% CI) versus healthy population) for incident depression associated with long-term cancer, cardiovascular disease, diabetes, and osteoarthritis were 1.19 (95% CI: 1.131.25), 1.08 (1.001.16)), 1.18 (1.091.28), and 1.94 (1.802.10), respectively. The corresponding HRs (95% CIs) for incident anxiety were 1.11 (1.031.20), 1.26 (1.141.39), 1.10 (0.981.24), and 2.01 (1.802.23), respectively. The positive association between cancer and incident depression was more evident in men (HR (95% CI): 1.24 (1.131.35) than in women (1.14 (1.071.21). Long-term diabetes was an independent risk factor for incident anxiety in men (1.21 (1.021.44) but not in women (1.09 (0.931.28)).

Interpretation: Long-term osteoarthritis, cardiovascular disease, and cancer were independent risk factors for incident depression and anxiety in both genders with osteoarthritis having the highest relative risk.

Item Details

Item Type:Refereed Article
Keywords:cardiovascular disease, cancer, diabetes, osteoarthritis, depression, anxiety
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Public Health and Health Services not elsewhere classified
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Mental Health
UTAS Author:Hill, E (Mr Edward Hill)
ID Code:134887
Year Published:2019
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-09-11
Last Modified:2019-09-11
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