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Haemopedia: an expression atlas of murine hematopoietic cells

Citation

de Graaf, CA and Choi, J and Baldwin, TM and Bolden, JE and Fairfax, KA and Robinson, AJ and Biben, C and Morgan, C and Ramsay, K and Ng, AP and Kauppi, M and Kruse, EA and Sargeant, TJ and Seidenman, N and D'Amico, A and D'Ombrain, MC and Lucas, EC and Koernig, S and Baz Morelli, A and Wilson, MJ and Dower, SK and Williams, B and Heazlewood, SY and Hu, Y and Nilsson, SK and Wu, L and Smyth, GK and Alexander, WS and Hilton, DJ, Haemopedia: an expression atlas of murine hematopoietic cells, Stem Cell Reports, 7, (3) pp. 571-582. ISSN 2213-6711 (2016) [Refereed Article]


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Copyright Statement

Copyright 2016 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

DOI: doi:10.1016/j.stemcr.2016.07.007

Abstract

Hematopoiesis is a multistage process involving the differentiation of stem and progenitor cells into distinct mature cell lineages. Here we present Haemopedia, an atlas of murine gene-expression data containing 54 hematopoietic cell types, covering all the mature lineages in hematopoiesis. We include rare cell populations such as eosinophils, mast cells, basophils, and megakaryocytes, and a broad collection of progenitor and stem cells. We show that lineage branching and maturation during hematopoiesis can be reconstructed using the expression patterns of small sets of genes. We also have identified genes with enriched expression in each of the mature blood cell lineages, many of which show conserved lineage-enriched expression in human hematopoiesis. We have created an online web portal called Haemosphere to make analyses of Haemopedia and other blood cell transcriptional datasets easier. This resource provides simple tools to interrogate gene-expression-based relationships between hematopoietic cell types and genes of interest.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Bioinformatics and computational biology
Research Field:Bioinformatic methods development
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Fairfax, KA (Dr Kirsten Fairfax)
ID Code:134789
Year Published:2016
Web of Science® Times Cited:43
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-09-05
Last Modified:2019-10-14
Downloads:9 View Download Statistics

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