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IL-10 regulates Aicda expression through miR-155

Citation

Fairfax, KA and Gantier, MP and Mackay, F and Williams, BRG and McCoy, CE, IL-10 regulates Aicda expression through miR-155, Journal of Leukocyte Biology, 97, (1) pp. 71-78. ISSN 0741-5400 (2015) [Refereed Article]

Copyright Statement

Copyright 2014 Society for Leukocyte Biology

DOI: doi:10.1189/jlb.2A0314-178R

Abstract

Aicda is a critical component of antibody class-switching in B cells. In this work, we study the impact of TLR4 activation and IL-10 stimulation on Aicda expression in B cells. Through the global analysis of miRNAs in response to TLR4 activation, in combination with IL-10 stimulation, we identified that IL-10 can suppress TLR4-induced miR-155 expression, an effect that resulted in enhanced Aicda expression. Furthermore, when preventing miR-155 control of Aicda expression, by genetic mutation of its target site in the Aicda mRNA, IL-10 could further potentiate Aicda expression. Given that miR-155 expression is lost, and expression levels of both Aicda and IL-10 are high in diseases, such as Burkitt's lymphoma, our results suggest a stringent and sophisticated control of Aicda by a novel IL-10/miR-155 axis, where the imbalance of IL-10 and/or miR-155 may contribute to disease pathogenesis.

Item Details

Item Type:Refereed Article
Keywords:AID, B cell, TLR4, antibody class-switching, interleukin, miRNA
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Cell Development, Proliferation and Death
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Immune System and Allergy
UTAS Author:Fairfax, KA (Dr Kirsten Fairfax)
ID Code:134781
Year Published:2015
Web of Science® Times Cited:10
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-09-04
Last Modified:2019-10-18
Downloads:0

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