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IL-10 regulates Aicda expression through miR-155
Citation
Fairfax, KA and Gantier, MP and Mackay, F and Williams, BRG and McCoy, CE, IL-10 regulates Aicda expression through miR-155, Journal of Leukocyte Biology, 97, (1) pp. 71-78. ISSN 0741-5400 (2015) [Refereed Article]
Copyright Statement
Copyright 2014 Society for Leukocyte Biology
DOI: doi:10.1189/jlb.2A0314-178R
Abstract
Aicda is a critical component of antibody class-switching in B cells. In this work, we study the impact of TLR4 activation and IL-10 stimulation on Aicda expression in B cells. Through the global analysis of miRNAs in response to TLR4 activation, in combination with IL-10 stimulation, we identified that IL-10 can suppress TLR4-induced miR-155 expression, an effect that resulted in enhanced Aicda expression. Furthermore, when preventing miR-155 control of Aicda expression, by genetic mutation of its target site in the Aicda mRNA, IL-10 could further potentiate Aicda expression. Given that miR-155 expression is lost, and expression levels of both Aicda and IL-10 are high in diseases, such as Burkitt's lymphoma, our results suggest a stringent and sophisticated control of Aicda by a novel IL-10/miR-155 axis, where the imbalance of IL-10 and/or miR-155 may contribute to disease pathogenesis.
Item Details
Item Type: | Refereed Article |
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Keywords: | AID, B cell, TLR4, antibody class-switching, interleukin, miRNA |
Research Division: | Biological Sciences |
Research Group: | Biochemistry and cell biology |
Research Field: | Cell development, proliferation and death |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Fairfax, KA (Dr Kirsten Fairfax) |
ID Code: | 134781 |
Year Published: | 2015 |
Web of Science® Times Cited: | 16 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2019-09-04 |
Last Modified: | 2019-10-18 |
Downloads: | 0 |
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