Davis, SR and Bell, RJ and Robinson, PJ and Handelsman, DJ and Gilbert, T and Phung, J and Desai, R and Lockery, JE and Woods, RL and Wolfe, RS and Reid, CM and Nelson, MR and Murray, AM and McNeil, JJ, Testosterone and estrone increase from the age of 70 years; findings from the Sex Hormones in Older Women Study, Journal of Clinical Endocrinology and Metabolism pp. 1-16. ISSN 0021-972X (2019) [Refereed Article]
Copyright © 2019 Endocrine Society
Objective: To determine whether sex steroid levels vary with age in and establish reference ranges for women beyond 70 years.
Design and Setting: Cross-sectional, community based, study.
Participants: 6392 women, aged 70 years and older.
Main Outcome Measures: Sex steroids measured by liquid chromatography-tandem mass spectrometry. A reference group, to establish sex steroid age-specific reference ranges, excluded women using systemic or topical sex steroid, anti-androgen or glucocorticoid therapy or an anti-glycaemic agent.
Results: The reference group of 5326 women had a mean age of 75·1 (± 4·2) years, range 70-94·7 years. Median values (range) were estrone (E1)181·2 pmol/L (3·7-5768·9), T 0·38 nmol/L (0·035-8·56), dehydroepiandrosterone (DHEA) 2·60 nmol/L (0·07-46·85) and SHBG 41·6 nmol/L (2·4-176·6). Estradiol and dihydrotestosterone were below method sensitivity in 66·1% and 72·7% of the samples, respectively. Compared with women aged 70-74 years, women aged 85+ years had higher median levels of E1 (11·7%, p=0·01), T (11·3%, p=0·02) and SHBG (22·7%, p<0·001) and lower DHEA (30% less, p<0·001). Overweight and obese women had higher E1 (p<0·001) and T (p<0·03), and lower SHBG (p<0·001) than women with normal body mass index. Smokers had 17·2% higher median T levels (p=0·005).
Conclusion: From the age of 70 years, T and E1 increase with age, despite a steady decline in DHEA. Whether E1 and T are biomarkers for longevity, or contribute to healthy aging merits investigation.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Endocrine Organs and Diseases (excl. Diabetes)|
|UTAS Author:||Nelson, MR (Professor Mark Nelson)|
|Web of Science® Times Cited:||2|
|Deposited By:||Menzies Institute for Medical Research|
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