eCite Digital Repository

Transcatheter aortic valve implantation for severe aortic stenosis in the Australian regional population


Paleri, S and Tham, JLM and Jin, D and Chan, YS and Wright, C and Baradi, A and Whitbourn, RJ and Adams, HSL and Palmer, SC, Transcatheter aortic valve implantation for severe aortic stenosis in the Australian regional population, Australian Journal of Rural Health, 27, (3) pp. 229-236. ISSN 1038-5282 (2019) [Refereed Article]

Copyright Statement

2019 National Rural Health Alliance Ltd.

DOI: doi:10.1111/ajr.12508


Objective: To compare clinical and functional outcomes of regional and urban pa-tients after transcatheter aortic valve implantation for severe aortic stenosis.

Methods: Data were collected at patient follow- up post- transcatheter aortic valve implantation at 30 days and 12 months. Patients were stratified by residential post-codes into remoteness areas using the Australian Statistical Geography Standard.

Design: Retrospective cohort study.

Setting: Single- centre tertiary referral hospital.

Participants: Patients undergoing transcatheter aortic valve implantation (n = 142) from 2009 to 2018 were analysed, with 77 patients (54.2%) residing in regional Victoria and New South Wales.

Main outcome measures: Procedural success, adverse event rates, readmission rates, mortality rates, loss to follow- up and functional improvement.

Results: Patients residing in regional areas had a lower mean age (81.8 vs 83.7 years) and proportion of Stage 4 or 5 chronic kidney disease (1.3% vs 9.2%), compared with urban patients. Procedural characteristics and immediate post- procedural outcomes were similar between both groups. There was no statistically significant difference in mortality, readmission rates or loss to follow- up between the two cohorts. Regional pa-tients demonstrated poorer rates of functional improvement at 30 days (50.7% vs 67.7%); however, this difference was not sustained at 12 months (79.2% vs 71.0%). Frailty was demonstrated to be an independent predictor of poor 30- day functional improvement.

Conclusion: Regional patients treated with transcatheter aortic valve implantation for severe aortic stenosis have non- inferior 30- day and 12- month outcomes, when compared with urban patients. Frailty is a predictor of poor functional improvement post- transcatheter aortic valve implantation.

Item Details

Item Type:Refereed Article
Keywords:cardiovascular medicine, health systems, models of regional service delivery, rural population health, therapeutics
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Adams, HSL (Dr Heath Adams)
ID Code:134599
Year Published:2019
Deposited By:Health Sciences
Deposited On:2019-08-22
Last Modified:2020-08-21

Repository Staff Only: item control page