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Renin-angiotensin-system, a potential pharmacological candidate, in acute respiratory distress syndrome during mechanical ventilation

Citation

Wang, D and Chai, X-q and Magnussen, CG and Zosky, GR and Shu, S-h and Wei, X and Hu, S-s, Renin-angiotensin-system, a potential pharmacological candidate, in acute respiratory distress syndrome during mechanical ventilation, Pulmonary Pharmacology and Therapeutics, 58 Article 101833. ISSN 1094-5539 (2019) [Refereed Article]

Copyright Statement

2019 Elsevier Ltd. All rights reserved.

DOI: doi:10.1016/j.pupt.2019.101833

Abstract

While effective treatments for acute respiratory distress syndrome (ARDS) are lacking, mechanical lung ventilation can sustain adequate gas exchange in critically ill patients with respiratory failure due to ARDS. However, as a result of the phenomenon of ventilator-induced lung injury (VILI), there is an increasing need to seek beneficial pharmacological therapies for ARDS. Recent studies have suggested the renin-angiotensin system (RAS), which consists of the ACE/Ang-II/AT1R axis and ACE2/Ang-(1-7)/MasR axis, plays a dual role in the pathogenesis of ARDS and VILI. This review highlights the deleterious action of ACE/Ang-II/AT1R axis and the beneficial role of ACE2/Ang-(1-7)/MasR axis, as well as AT2R, in VILI and ARDS, and also discusses the possibility of targeting RAS components with pharmacological interventions to improve outcomes in ARDS.

Item Details

Item Type:Refereed Article
Keywords:Acute respiratory distress syndrome (ARDS), Mechanical ventilation, Renin-angiotensin system (RAS), ventilator-induced lung injury (VILI)
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
UTAS Author:Magnussen, CG (Dr Costan Magnussen)
UTAS Author:Zosky, GR (Professor Graeme Zosky)
ID Code:134589
Year Published:2019
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-08-21
Last Modified:2019-09-12
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