While effective treatments for acute respiratory distress syndrome (ARDS) are lacking, mechanical lung ventilation can sustain adequate gas exchange in critically ill patients with respiratory failure due to ARDS. However, as a result of the phenomenon of ventilator-induced lung injury (VILI), there is an increasing need to seek beneficial pharmacological therapies for ARDS. Recent studies have suggested the renin-angiotensin system (RAS), which consists of the ACE/Ang-II/AT1R axis and ACE2/Ang-(1-7)/MasR axis, plays a dual role in the pathogenesis of ARDS and VILI. This review highlights the deleterious action of ACE/Ang-II/AT1R axis and the beneficial role of ACE2/Ang-(1-7)/MasR axis, as well as AT2R, in VILI and ARDS, and also discusses the possibility of targeting RAS components with pharmacological interventions to improve outcomes in ARDS.

Item Type:	Refereed Article
Keywords:	Acute respiratory distress syndrome (ARDS), Mechanical ventilation, Renin-angiotensin system (RAS), ventilator-induced lung injury (VILI)
Research Division:	Biomedical and Clinical Sciences
Research Group:	Cardiovascular medicine and haematology
Research Field:	Cardiology (incl. cardiovascular diseases)
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Clinical health not elsewhere classified
UTAS Author:	Magnussen, CG (Associate Professor Costan Magnussen)
UTAS Author:	Zosky, GR (Professor Graeme Zosky)
ID Code:	134589
Year Published:	2019
Web of Science® Times Cited:	41
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2019-08-21
Last Modified:	2022-08-25
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