eCite Digital Repository

Effects of intermittent versus continuous energy intakes on insulin sensitivity and metabolic risk in women with overweight


Hutchison, AT and Liu, B and Wood, RE and Vincent, AD and Thompson, CH and O'Callaghan, NJ and Wittert, GA and Heilbronn, LK, Effects of intermittent versus continuous energy intakes on insulin sensitivity and metabolic risk in women with overweight, Obesity, 27, (1) pp. 50-58. ISSN 1930-7381 (2019) [Refereed Article]

Copyright Statement

2018 The Obesity Society

DOI: doi:10.1002/oby.22345


Objective: This study aimed to compare intermittent fasting (IF) versus continuous energy intakes at 100% or 70% of calculated energy requirements on insulin sensitivity, cardiometabolic risk, body weight, and composition.

Methods: Women with overweight (n=88; 501 years, BMI 32.30.5 kg/m2) were randomized to one of four diets (IF70, IF100, dietary restriction [DR70], or control) in a 2:2:2:1 ratio for 8 weeks. IF groups fasted for 24 hours after breakfast on three nonconsecutive days per week. All foods were provided and diets matched for macronutrient composition (35% fat, 15% protein, 50% carbohydrate). Insulin sensitivity by hyperinsulinemic-euglycemic clamp, weight, body composition, and plasma markers were assessed following a "fed" day (12-hour fast) and a 24-hour fast (IF only).

Results: displayed greater reductions in weight, fat mass, total- and low-density lipoprotein cholesterol, and nonesterified fatty acids compared with DR70 and IF100 (all P≤0.05). IF100 lost more weight and fat than control. However, fasting insulin was increased. There were no group differences in insulin sensitivity by clamp; however, a 24-hour fast transiently reduced insulin sensitivity.

Conclusions: When prescribed at matched energy restriction, IF reduced weight and fat mass and improved total and low-density lipoprotein cholesterol more than DR. IF prescribed in energy balance did not improve health compared with other groups, despite modest weight loss.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Nutrition and dietetics
Research Field:Nutritional science
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Nutrition
UTAS Author:Wood, RE (Dr Rachel Wood)
ID Code:134576
Year Published:2019 (online first 2018)
Web of Science® Times Cited:56
Deposited By:Health Sciences
Deposited On:2019-08-21
Last Modified:2020-08-21

Repository Staff Only: item control page