Pare, M and Goupil, R and Fortier, C and Mac-Way, F and Madore, F and Marquis, K and Hametner, B and Wassertheurer, S and Schultz, MG and Sharman, JE and Agharazii, M, Determinants of increased central excess pressure in dialysis: role of dialysis modality and arteriovenous fistula, American Journal of Hypertension pp. 1-28. ISSN 0895-7061 (2019) [Refereed Article]
|PDF (Accepted Manuscript)|
Available from 18 August 2020
Copyright 2019 American Journal of Hypertension, Ltd.
Method: In a cross-sectional study, 290 subjects (232 HD, and 130 with AVF) underwent carotid artery tonometry (calibrated with brachial diastolic and mean blood pressure). The XSPI was calculated through RWA using pressure-only algorithms. Logistic regression was used for determinants of XSPI above median. Through forward conditional linear regression, we examined whether treatment by HD or presence of AVF is associated with higher XSPI.
Results: Patients with XSPI> median were older, had a higher prevalence of diabetes and cardiovascular disease, had a higher body mass index and were more likely to be on HD. After adjustment for confounders, HD was associated with a higher risk of higher XSPI (OR=2.39, 95%CI:1.16-4.98). In a forward conditional linear regression analysis, HD was associated with higher XSPI (standardized coefficient: 0.126, P=0.012), but upon incorporation of AVF into the model, AVF was associated with higher XSPI (standardized coefficient: 0.130, P=0.008) and HD was excluded as a predictor.
Conclusion: This study suggests that higher XSPI in HD patients is related to the presence of AVF.
|Item Type:||Refereed Article|
|Keywords:||arteriovenous fistula, dialysis, end-stage renal disease, excess pressure, pulse wave velocity, reservoir-wave approach, wave separation analysis|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|UTAS Author:||Schultz, MG (Dr Martin Schultz)|
|UTAS Author:||Sharman, JE (Professor James Sharman)|
|Web of Science® Times Cited:||1|
|Deposited By:||Menzies Institute for Medical Research|
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