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Acetylcholine dynamically controls spatial integration in marmoset primary visual cortex

Citation

Roberts, MJ and Zinke, W and Guo, K and Robertson, R and McDonald, JS and Thiele, A, Acetylcholine dynamically controls spatial integration in marmoset primary visual cortex, Journal of Neurophysiology, 93, (4) pp. 2062-2072. ISSN 0022-3077 (2005) [Refereed Article]

Copyright Statement

Copyright 2005 The American Physiological Society

DOI: doi:10.1152/jn.00911.2004

Abstract

Recent in vitro studies have shown that acetylcholine (ACh) selectively reduces the efficacy of lateral cortical connections via a muscarinic mechanism, while boosting the efficacy of thalamocortical/feed-forward connections via a nicotinic mechanism. This suggests that high levels of ACh should reduce center-surround interactions of neurons in primary visual cortex, making cells more reliant on feed-forward information. In line with this hypothesis, we show that local iontophoretic application of ACh in primate primary visual cortex reduced the extent of spatial integration, assessed by recording a neurons' length tuning. When ACh was externally applied, neurons' preferred length shifted toward shorter bars, showing reduced impact of the extra-classical receptive field. We fitted a difference and a ratio of Gaussian model to these data to determine the underlying mechanisms of this dynamic change of spatial integration. These models assume overlapping summation and suppression areas with different widths and gains to be responsible for spatial integration and size tuning. ACh significantly reduced the extent of the summation area, but had no significant effect on the extent of the suppression area. In line with previous studies, we also show that applying ACh enhanced the response in the majority of cells, especially in the later (sustained) part of the response. These findings are similar to effects of attention on neuronal activity. The natural release of ACh is strongly linked with states of arousal and attention. Our results may therefore be relevant to the neurobiological mechanism of attention.

Item Details

Item Type:Refereed Article
Keywords:primary visual cortex, spatial integration, acetylcholine
Research Division:Biological Sciences
Research Group:Zoology
Research Field:Animal neurobiology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:McDonald, JS (Dr Scott McDonald)
ID Code:134501
Year Published:2005
Web of Science® Times Cited:93
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2019-08-15
Last Modified:2019-09-13
Downloads:0

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