134484 - Chiral selectors in capillary electrophoresis.pdf (2.56 MB)
Chiral selectors in capillary electrophoresis: trends during 2017–2018
journal contribution
posted on 2023-05-20, 06:23 authored by Raymond Fernando Yu, Joselito QuirinoChiral separation is an important process in the chemical and pharmaceutical industries. From the analytical chemistry perspective, chiral separation is required for assessing the fit-for-purpose and the safety of chemical products. Capillary electrophoresis, in the electrokinetic chromatography mode is an established analytical technique for chiral separations. A water-soluble chiral selector is typically used. This review therefore examines the use of various chiral selectors in electrokinetic chromatography during 2017–2018. The chiral selectors were both low and high (macromolecules) molecular mass molecules as well as molecular aggregates (supramolecules). There were 58 papers found by search in Scopus, indicating continuous and active activity in this research area. The macromolecules were sugar-, amino acid-, and nucleic acid-based polymers. The supramolecules were bile salt micelles. The low molecular mass selectors were mainly ionic liquids and complexes with a central ion. A majority of the papers were on the use or preparation of sugar-based macromolecules, e.g., native or derivatised cyclodextrins. Studies to explain chiral recognition of macromolecular and supramolecular chiral selectors were mainly done by molecular modelling and nuclear magnetic resonance spectroscopy. Demonstrations were predominantly on drug analysis for the separation of racemates.
Funding
Australian Research Council
History
Publication title
MoleculesVolume
24Issue
6Article number
1135Number
1135Pagination
1-18ISSN
1420-3049Department/School
School of Natural SciencesPublisher
Molecular Diversity Preservation InternationalPlace of publication
Matthaeusstrasse 11, Basel, Switzerland, Ch-4057Rights statement
© 2019 by the authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/Repository Status
- Open