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Chiral selectors in capillary electrophoresis: trends during 20172018

Citation

Yu, RB and Quirino, JP, Chiral selectors in capillary electrophoresis: trends during 2017-2018, Molecules, 24, (6) Article 1135. ISSN 1420-3049 (2019) [Refereed Article]


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Copyright Statement

2019 by the authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3390/molecules24061135

Abstract

Chiral separation is an important process in the chemical and pharmaceutical industries. From the analytical chemistry perspective, chiral separation is required for assessing the fit-for-purpose and the safety of chemical products. Capillary electrophoresis, in the electrokinetic chromatography mode is an established analytical technique for chiral separations. A water-soluble chiral selector is typically used. This review therefore examines the use of various chiral selectors in electrokinetic chromatography during 2017"2018. The chiral selectors were both low and high (macromolecules) molecular mass molecules as well as molecular aggregates (supramolecules). There were 58 papers found by search in Scopus, indicating continuous and active activity in this research area. The macromolecules were sugar-, amino acid-, and nucleic acid-based polymers. The supramolecules were bile salt micelles. The low molecular mass selectors were mainly ionic liquids and complexes with a central ion. A majority of the papers were on the use or preparation of sugar-based macromolecules, e.g., native or derivatised cyclodextrins. Studies to explain chiral recognition of macromolecular and supramolecular chiral selectors were mainly done by molecular modelling and nuclear magnetic resonance spectroscopy. Demonstrations were predominantly on drug analysis for the separation of racemates.

Item Details

Item Type:Refereed Article
Keywords:chiral separation, capillary electrophoresis
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
UTAS Author:Yu, RB (Mr Raymond Yu)
UTAS Author:Quirino, JP (Associate Professor Lito Quirino)
ID Code:134484
Year Published:2019
Funding Support:Australian Research Council (DP180102810)
Web of Science® Times Cited:1
Deposited By:Chemistry
Deposited On:2019-08-14
Last Modified:2019-09-06
Downloads:4 View Download Statistics

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