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Dual gold‐catalyzed cycloaromatization of unconjugated (E)‐enediynes
journal contribution
posted on 2023-05-20, 06:19 authored by Zamani, F, Rasool BabaahmadiRasool Babaahmadi, Brian YatesBrian Yates, Michael GardinerMichael Gardiner, Alireza AriafardAlireza Ariafard, Pyne, SG, Hyland, CJTA synthesis of unconjugated (E)‐enediynes from allenyl amino alcohols is reported and their gold‐catalyzed cascade cycloaromatization to a broad range of enantioenriched substituted isoindolinones has been developed. Experimental and computational studies support the reaction proceeding via a dual‐gold σ,π‐activation mode, involving a key gold‐vinylidene‐ and allenyl‐gold‐containing intermediate.
Funding
Australian Research Council
University of Wollongong
History
Publication title
Angewandte ChemieVolume
58Issue
7Pagination
2114 -2119ISSN
0044-8249Department/School
School of Natural SciencesPublisher
WileyPlace of publication
GermanyRights statement
Copyright 2019 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimRepository Status
- Restricted