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Clomiphene citrate and pregnancy outcome

journal contribution
posted on 2023-05-20, 06:10 authored by Alison VennAlison Venn, Lumley, J
Data from Australia and elsewhere have shown consistently that adverse perinatal outcomes such as preterm birth and perinatal mortality are more common in pregnancies resulting from assisted conception with IVF and GIFT than normally conceived pregnancies. Factors that may contribute to the excess of poor outcomes include maternal factors, the assisted conception procedures themselves and possibly the influence of drugs used to induce superovulation. This review examines the medical literature describing pregnancies following ovulation induction with one of the drugs used to induce superovulation, clomiphene citrate, and compares their outcomes with Australian IVF and GIFT pregnancy outcomes. The review shows that whilst some studies have suggested higher rates of ectopic pregnancy, spontaneous abortion and congenital malformations in clomiphene citrate induced pregnancies, the findings are inconsistent and the data are flawed. There are only very poor data available on the incidence of preterm birth. Multiple pregnancy is a well-recognized adverse outcome of clomiphene citrate induced pregnancies. Attempts to improve perinatal outcomes of pregnancies following assisted conception will be helped by a better understanding of the relative contributions of maternal and treatment factors and further studies of pregnancy outcome after ovulation induction are needed.

History

Publication title

Australian and New Zealand Journal of Obstetrics and Gynecology

Volume

34

Pagination

56-66

ISSN

0004-8666

Department/School

Menzies Institute for Medical Research

Publisher

Royal Australian N Z College Obstetricians & Gynecologists

Place of publication

254-260 Albert St, East Melbourne, Australia, Vic, 3002

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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