Si, L and Tu, L and Xie, Y and Palmer, AJ and Gu, Y and Zheng, X and Li, J and Lv, Q and Qi, J and Lin, Z and Chen, M and Gu, J and Hiligsmann, M, Chinese patients' preference for pharmaceutical treatments of osteoporosis: a discrete choice experiment, Archives of Osteoporosis, 14, (1) Article 85. ISSN 1862-3522 (2019) [Refereed Article]
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Copyright International Osteoporosis Foundation and National Osteoporosis Foundation 2019
Purpose: This study was performed to elicit Chinese patients' preferences for osteoporosis medication treatment and to investigate the heterogeneities of the preferences in subgroups.
Methods: A discrete choice experiment comprising 15 choice sets with 4 important attributes was conducted in a Chinese population at risk of osteoporotic fracture. The four attributes were treatment efficacy in reducing the risk of fracture, out-of-pocket cost per year, adverse effects of treatment, and mode of administration. The patients were asked to choose between two hypothetical treatments; they could also choose no treatment. Mixed logit models were used, and any observed heterogeneity in the patients' preferences was further assessed in subgroup analyses.
Results: In total, 267 patients were analysed. On average, the patients preferred to receive treatment rather than no treatment. The patients preferred treatment with higher efficacy in preventing fracture and lower out-of-pocket cost. The least preferred adverse effect of medication was gastrointestinal disorders, followed by flu-like symptoms and finally skin reactions. The most preferred mode of administration was annual intravenous infusion, followed by 6-month subcutaneous injection, a weekly oral tablet, and daily nasal spray; daily oral tablets ranked as the least preferred mode of administration. The differences in the patients' preferences among all attributes were statistically significant (p < 0.05). Patients' age was found to contribute to the observed preference heterogeneity in most of the included attributes.
Conclusions: This study revealed Chinese patients' preferences for osteoporosis treatments. Annual intravenous infusion and 6-month subcutaneous injection were significantly preferred over weekly oral tablets in this Chinese population.
|Item Type:||Refereed Article|
|Keywords:||Chinese, discrete choice experiment, osteoporosis, patient preferences, pharmaceutical treatment|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Research Field:||Rheumatology and arthritis|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Behaviour and health|
|UTAS Author:||Palmer, AJ (Professor Andrew Palmer)|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||5 View Download Statistics|
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