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Microbiome-focused asthma management strategies


Shukla, SD and Shastri, MD and Chong, WC and Dua, K and Budden, KF and Mahmood, MQ and Hansbro, NG and Keely, S and Eri, R and Patel, RP and Peterson, GM and Hansbro, PM, Microbiome-focused asthma management strategies, Current Opinion in Pharmacology, 46 pp. 143-149. ISSN 1471-4892 (2019) [Refereed Article]

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Copyright 2019 Elsevier Ltd. All rights reserved.

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DOI: doi:10.1016/j.coph.2019.06.003


Asthma is a common, heterogeneous and serious disease with high prevalence globally. Poorly controlled, steroid-resistant asthma is particularly important as there are no effective therapies and it exerts substantial healthcare and societal burden. The role of microbiomes, particularly in chronic diseases has generated considerable interest in recent times. Existing evidence clearly demonstrates an association between asthma initiation and the microbiome, both respiratory and gastro-intestinal, although its' roles are poorly understood when assessing the asthma progression or heterogeneity (i.e. phenotypes/endotypes) across different geographical locations. Moreover, modulating microbiomes could be preventive and/or therapeutic in patients with asthma warrants urgent attention. Here, we review recent advances in assessing the role of microbiomes in asthma and present the challenges associated with the potential therapeutic utility of modifying microbiomes in management.

Item Details

Item Type:Refereed Article
Keywords:asthma, microbiome, management, pharmacology, inflammation
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Shastri, MD (Mr Madhur Shastri)
UTAS Author:Mahmood, MQ (Mr Malik Mahmood)
UTAS Author:Eri, R (Associate Professor Raj Eri)
UTAS Author:Patel, RP (Dr Rahul Patel)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
ID Code:134246
Year Published:2019
Web of Science® Times Cited:6
Deposited By:Pharmacy
Deposited On:2019-08-02
Last Modified:2020-08-07

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