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The contribution of geogenic particulate matter to lung disease in indigenous children

Citation

Shepherd, CCJ and Clifford, HD and Mitrou, F and Melody, SM and Bennett, EJ and Johnston, FH and Knibbs, LD and Pereira, G and Pickering, JL and Teo, TH and Kirkham, LS and Thornton, RB and Kicic, A and Ling, K-M and Alach, Z and Lester, M and Franklin, P and Reid, D and Zosky, GR, The contribution of geogenic particulate matter to lung disease in indigenous children, International Journal of Environmental Research and Public Health, 16, (15) Article 2636. ISSN 1661-7827 (2019) [Refereed Article]


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Copyright 2019 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3390/ijerph16152636

Abstract

Indigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the relationship between dust levels and health in Indigenous children in Western Australia (W.A.). Data were from a population-based sample of 1077 Indigenous children living in 66 remote communities of W.A. (>2,000,000 km2), with information on health outcomes derived from carer reports and hospitalisation records. Associations between dust levels and health outcomes were assessed by multivariate logistic regression in a multi-level framework. We assessed the effect of exposure to community sampled PM on epithelial cell (NuLi-1) responses to non-typeable Haemophilus influenzae (NTHi) in vitro. High dust levels were associated with increased odds of hospitalisation for upper (OR 1.77 95% CI [1.02-3.06]) and lower (OR 1.99 95% CI [1.08-3.68]) respiratory tract infections and ear disease (OR 3.06 95% CI [1.20-7.80]). Exposure to PM enhanced NTHi adhesion and invasion of epithelial cells and impaired IL-8 production. Exposure to geogenic PM may be contributing to the poor respiratory health of disadvantaged communities in arid environments where geogenic PM levels are high.

Item Details

Item Type:Refereed Article
Keywords:indigenous health, geogenic PM, indigenous, bacterial infection, child health, geogenic, particulate matter
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Aboriginal and Torres Strait Islander Health
Objective Division:Health
Objective Group:Indigenous Health
Objective Field:Aboriginal and Torres Strait Islander Health - Determinants of Health
UTAS Author:Melody, SM (Dr Shannon Melody)
UTAS Author:Bennett, EJ (Ms Ellen Bennett)
UTAS Author:Johnston, FH (Associate Professor Fay Johnston)
UTAS Author:Zosky, GR (Professor Graeme Zosky)
ID Code:134108
Year Published:2019
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-07-26
Last Modified:2019-08-05
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