eCite Digital Repository

Activity of natural and synthetic polygodial derivatives against Trypanosoma cruzi amastigotes, trypomastigotes and epimastigotes

Citation

Turner, DN and Just, J and Dasari, R and Smith, JA and Bissember, AC and Kornienko, A and Rogelj, S, Activity of natural and synthetic polygodial derivatives against Trypanosoma cruzi amastigotes, trypomastigotes and epimastigotes, Natural Product Research pp. 1-4. ISSN 1478-6419 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 Informa UK Limited, trading as Taylor & Francis Group

DOI: doi:10.1080/14786419.2019.1597350

Abstract

Our laboratories have been investigating biological effects of a sesquiterpenoid polygodial and its natural and synthetic analogues. Herein, we report the evaluation of these compounds against the three forms of Trypanosoma cruzi, amastigotes, trypomastigotes and epimastigotes. Although polygodial was found to be poorly active, its natural congener epipolygodial and synthetic Wittig-derived analogues showed low micromolar potency against all three forms of the parasite. Synthetic α,β-unsaturated phosphonate 9 compared favorably with clinically approved drugs benznidazole and nifurtimox, and was effective against trypomastigotes, toward which benznidazole showed no activity.

Item Details

Item Type:Refereed Article
Keywords:Trypanosoma cruzi, polygodial, phosphonate
Research Division:Chemical Sciences
Research Group:Organic Chemistry
Research Field:Natural Products Chemistry
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
UTAS Author:Just, J (Mr Jeremy Just)
UTAS Author:Smith, JA (Associate Professor Jason Smith)
UTAS Author:Bissember, AC (Dr Alex Bissember)
ID Code:134078
Year Published:2019
Deposited By:Chemistry
Deposited On:2019-07-25
Last Modified:2019-12-24
Downloads:0

Repository Staff Only: item control page