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Epithelial–mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics

Citation

Eapen, MS and Sharma, P and Gaikwad, AV and Lu, W and Myers, S and Hansbro, PM and Sohal, SS, Epithelial-mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics, International Journal of Chronic Obstructive Pulmonary Disease, 14 pp. 1603-1610. ISSN 1178-2005 (2019) [Letter or Note in Journal]


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DOI: doi:10.2147/COPD.S208428

Abstract

COPD is a common and highly destructive disease with huge impacts on people and health services throughout the world. It is mainly caused by cigarette smoking though environmental pollution is also significant. There are no current treatments that affect the overall course of COPD; current drugs focus on symptomatic relief and to some extent reducing exacerbation rates. There is an urgent need for in-depth studies of the fundamental pathogenic mechanisms that underpin COPD. This is vital, given the fact that nearly 40%–60% of the small airway and alveolar damage occurs in COPD well before the first measurable changes in lung function are detected. These individuals are also at a high risk of lung cancer. Current COPD research is mostly centered around late disease and/or innate immune activation within the airway lumen, but the actual damage to the airway wall has early onset. COPD is the end result of complex mechanisms, possibly triggered through initial epithelial activation. To change the disease trajectory, it is crucial to understand the mechanisms in the epithelium that are switched on early in smokers. One such mechanism we believe is the process of epithelial to mesenchymal transition. This article highlights the importance of this profound epithelial cell plasticity in COPD and also its regulation. We consider that understanding early changes in COPD will open new windows for therapy.

Item Details

Item Type:Letter or Note in Journal
Keywords:COPD, lung cancer, epithelium, EMT, epithelium to mesenchymal transition
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
UTAS Author:Eapen, MS (Mr Mathew Eapen)
UTAS Author:Sharma, P (Dr Pawan Sharma)
UTAS Author:Gaikwad, AV (Ms Archana Gaikwad)
UTAS Author:Lu, W (Dr Monica Lu)
UTAS Author:Myers, S (Dr Stephen Myers)
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:134060
Year Published:2019
Deposited By:Health Sciences
Deposited On:2019-07-24
Last Modified:2019-07-24
Downloads:0

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