Zhang, X and Yuan, Y and Pan, Z and Ma, Y and Wu, M and Yang, J and Han, R and Chen, M and Hu, X and Liu, R and Sam, NB and Xu, S and Pan, F, Elevated circulating IL-17 level is associated with inflammatory arthritis and disease activity: A meta-analysis, Clinica Chimica Acta, 496 pp. 76-83. ISSN 0009-8981 (2019) [Refereed Article]
© 2019 Elsevier B.V. All rights reserved.
Methods: Relevant studies were searched using databases. Standardized mean difference (SMD) was calculated. Correlation coefficient was utilized to evaluate the relationship between IL-17 and disease activity of AS and RA. Subgroup analysis, sensitivity analysis and meta-regression were applied to explore the sources of heterogeneity.
Results: 83 records were enrolled. The IL-17 level was elevated in AS (SMD = 2.348, P < .001), RA (SMD = 1.502, P < .001), PsA (SMD = 1.710, P < .001) and OA (SMD = 1.192, P = .016), and similar results occurred in subgroup analysis. Furthermore, the IL-17 level was positively associated with disease activity of AS and RA.
Conclusion: Circulating IL-17 level is significantly elevated in inflammatory arthritis and is related to the disease activity of AS and RA, suggesting that it plays an important role in the pathogenesis and progression of inflammatory arthritis (especially in AS and RA).
|Item Type:||Refereed Article|
|Keywords:||arthritis, cytokines, IL-17, inflammatory arthritis, interleukin-17|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|UTAS Author:||Zhang, X (Mr Xu Zhang)|
|UTAS Author:||Pan, F (Professor Faming Pan)|
|Web of Science® Times Cited:||3|
|Deposited By:||Menzies Institute for Medical Research|
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