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Telomere length and vascular phenotypes in a population-based cohort of children and midlife adults

Citation

Nguyen, MT and Vryer, R and Ranganathan, S and Lycett, K and Grobler, A and Dwyer, T and Juonala, M and Saffery, R and Burgner, D and Wake, M, Telomere length and vascular phenotypes in a population-based cohort of children and midlife adults, Journal of the American Heart Association, 8, (11) Article e012707. ISSN 2047-9980 (2019) [Refereed Article]


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Copyright 2019 the author. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/

DOI: doi:10.1161/JAHA.119.012707

Abstract

Background: Telomere length has been inversely associated with cardiovascular disease in adulthood, but its relationship to preclinical cardiovascular phenotypes across the life course remains unclear. We investigated associations of telomere length with vascular structure and function in children and midlife adults.

Methods and Results: Population-based cross-sectional CheckPoint (Child Health CheckPoint) study of 11- to 12-year-old children and their parents, nested within the LSAC (Longitudinal Study of Australian Children). Telomere length (telomeric genomic DNA [T]/β-globin single-copy gene [S] [T/S ratio]) was measured by quantitative polymerase chain reaction from blood-derived genomic DNA. Vascular structure was assessed by carotid intima-media thickness, and vascular function was assessed by carotid-femoral pulse-wave velocity and carotid elasticity. Mean (SD) T/S ratio was 1.09 (0.55) in children (n=1206; 51% girls) and 0.81 (0.38) in adults (n=1343; 87% women). Linear regression models, adjusted for potential confounders, revealed no evidence of an association between T/S ratio and carotid intima-media thickness, carotid-femoral pulse-wave velocity, or carotid elasticity in children. In adults, longer telomeres were associated with greater carotid elasticity (0.14% per 10-mm Hg higher per unit of T/S ratio; 95% CI, 0.04%-0.2%; P=0.007), but not carotid intima-media thickness (-0.9 μm; 95% CI, -14 to 13 μm; P=0.9) or carotid-femoral pulse-wave velocity (-0.10 m/s; 95% CI, -0.3 to 0.07 m/s; P=0.2). In logistic regression analysis, telomere length did not predict poorer vascular measures at either age.

Conclusions: In midlife adults, but not children, there was some evidence that telomere length was associated with vascular elasticity but not thickness. Associations between telomere length and cardiovascular phenotypes may become more evident in later life, with advancing pathological changes.

Item Details

Item Type:Refereed Article
Keywords:CheckPoint (Child Health CheckPoint) study, LSAC (Longitudinal Study of Australian Children), aging, arterial stiffness, atherosclerosis, carotid intima‐media thickness, pulse‐wave velocity
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
UTAS Author:Dwyer, T (Professor Terry Dwyer)
ID Code:134045
Year Published:2019
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-07-23
Last Modified:2019-08-05
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