Cheung, NK and Carr, MW and Ray, U and McKenzie, D and Froelich, JJ, Platelet function testing in neurovascular procedures: tool or gimmick?, Interventional Neurology, 8 pp. 123-134. ISSN 1664-9737 (2019) [Refereed Article]
© 2019 S. Karger AG, Basel
Objective: This study was conducted to compare differences in thromboembolic complication rates associated with NVS in platelet-inhibited patients with and without PFT. Clinical neurological outcomes were assessed by differences in the modified Rankin Scale (mRS).
Materials and Methods: One hundred seventeen consecutive patients underwent elective NVS procedures within a 7-year period. All patients received aspirin and clopidogrel 8 days before the procedure. Fifty-Two patients were treated without assessment of platelet inhibition, and 65 patients were tested for clopidogrel resistance. When clopidogrel resistance was revealed, corresponding patients were converted to ticagrelor. Changes in mRS and thromboembolic event rates were compared between the 2 cohorts.
Results: Thirty-five percent of patients from the cohort subjected to PFT tests showed inadequate platelet inhi-bition under clopidogrel and were converted to ticagrelor. Compared to the non-PFT test-cohort, neurological deficits were significantly reduced (12 vs. 0%; p = 0.009) and a lower number of thromboembolic events was found (12 vs. 3%; p > 0.05) within the test cohort.
Conclusion: PFT appears to identify patients with clopidogrel resistance prior to NVS procedures. When non-responders are converted to alternative platelet inhibitors, neurological outcomes and thromboembolic complication rates may improve. Consequently, this study provides preliminary evidence that PFT may be a useful clinical tool to enhance procedural safety and improve clinical outcomes in NVS procedures.
|Item Type:||Refereed Article|
|Keywords:||platelet function testing, platelet inhibition, neurovascular stenting, intracranial aneurysms, coiling|
|Research Division:||Biomedical and Clinical Sciences|
|Research Field:||Neurology and neuromuscular diseases|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Cheung, NK (Dr Nicholas Cheung)|
|UTAS Author:||Ray, U (Associate Professor Udayan Ray)|
|UTAS Author:||Froelich, JJ (Professor Jens Froelich)|
|Web of Science® Times Cited:||4|
|Deposited By:||Menzies Institute for Medical Research|
Repository Staff Only: item control page