Pridmore, S and Erger, S and May, T, Second courses of transcranial magnetic stimulation (TMS) in major depressive episodes for initial responders and non-responders, Malaysian Journal of Medical Sciences, 26, (3) pp. 102-109. ISSN 1394-195X (2019) [Refereed Article]
Copyright 2019 Penerbit Universiti Sains Malaysia. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Background: Transcranial Magnetic Stimulation (TMS) is effective in major depressive episodes (MDE). However, MDE may follow a chronic, relapsing course, and some individuals may not satisfactorily respond to a first course of TMS.
Objective: To investigate the outcome of second courses of TMS.
Method: A naturalistic investigation—we prospectively studied 30 MDE in-patients and routinely collected information, including pre- and post-treatment with Six-item Hamilton Depression Rating Scale (HAMD6), a six-item Visual Analogue Scale (VAS6) and the Clinical Global Impression-Severity (CGI-S). Two categories of patients were considered: i) those who had remitted with a first course, but relapsed, and ii) those who had not remitted with the first course.
Results: Thirty individuals received a second TMS course. The mean time to the second course was 27.5 weeks. Based on the HAMD6, 26 (87%) achieved remission after the first course, and 22 (73%) achieved remission after the second course. Furthermore, based on the HAMD6 results, of the four patients who did not achieve remission with a first course, three (75%) did so with a second course.
Conclusion: In MDE, a second course of TMS is likely to help those who remitted to a first course and then relapsed, as well as those who did not achieve remission with a first course.
|Item Type:||Refereed Article|
|Keywords:||transcranial magnetic stimulation, depression, neurostimulation|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Psychiatry (incl. Psychotherapy)|
|Objective Group:||Public Health (excl. Specific Population Health)|
|Objective Field:||Mental Health|
|UTAS Author:||Pridmore, S (Professor Saxby Pridmore)|
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