Barnabe, C and Toepfer, D and Marotte, H and Hauge, E-M and Scharmga, A and Kocijan, R and Kraus, S and Boutroy, S and Schett, G and Keller, KK and de Jong, J and Stok, K and Finzel, S, SPECTRA Collaboration, Definition for rheumatoid arthritis erosions imaged with high resolution peripheral quantitative computed tomography and interreader reliability for detection and measurement, Journal of Rheumatology, 43, (10) pp. 1935-1940. ISSN 0315-162X (2016) [Refereed Article]
The Journal of Rheumatology Copyright © 2016. All rights reserved.
Objective: High-resolution peripheral quantitative computed tomography (HR-pQCT) sensitively detects erosions in rheumatoid arthritis (RA); however, nonpathological cortical bone disruptions are potentially misclassified as erosive. Our objectives were to set and test a definition for pathologic cortical bone disruptions in RA and to standardize reference landmarks for measuring erosion size.
Methods: HR-pQCT images of metacarpophalangeal joints of RA and control subjects were used in an iterative process to achieve consensus on the definition and reference landmarks. Independent readers (n = 11) applied the definition to score 58 joints and measure pathologic erosions in 2 perpendicular multiplanar reformations for their maximum width and depth. Interreader reliability for erosion detection and variability in measurements between readers [root mean square coefficient of variation (RMSCV), intraclass correlation (ICC)] were calculated.
Results: Pathologic erosions were defined as cortical breaks extending over a minimum of 2 consecutive slices in perpendicular planes, with underlying trabecular bone loss and a nonlinear shape. Interreader agreement for classifying pathologic erosions was 90.2%, whereas variability for width and depth erosion assessment was observed (RMSCV perpendicular width 12.3%, axial width 20.6%, perpendicular depth 24.0%, axial depth 22.2%; ICC perpendicular width 0.206, axial width 0.665, axial depth 0.871, perpendicular depth 0.783). Mean erosion width was 1.84 mm (range 0.16-8.90) and mean depth was 1.86 mm (range 0.30-8.00).
Conclusion: We propose a new definition for erosions visualized with HR-pQCT imaging. Interreader reliability for erosion detection is good, but further refinement of selection of landmarks for erosion size measurement, or automated volumetric methods, will be pursued.
|Item Type:||Refereed Article|
|Keywords:||erosions, HR-pQCT, rheumatoid arthritis|
|Research Group:||Biomedical engineering|
|Research Field:||Biomechanical engineering|
|Objective Division:||Expanding Knowledge|
|Objective Group:||Expanding knowledge|
|Objective Field:||Expanding knowledge in engineering|
|UTAS Author:||Stok, K (Dr Kathryn Stok)|
|Web of Science® Times Cited:||42|
|Deposited By:||Menzies Institute for Medical Research|
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