Tom, S and Frayne, M and Manske, SL and Burghardt, AJ and Stok, KS and Boyd, SK and Barnabe, C, Determining metacarpophalangeal flexion angle tolerance for reliable volumetric joint space measurements by high-resolution peripheral quantitative computed tomography, Journal of Rheumatology, 43, (10) pp. 1941-1944. ISSN 0315-162X (2016) [Refereed Article]
Copyright 216 The Journal of Rheumatology
Objective: The position-dependence of a method to measure the joint space of metacarpophalangeal (MCP) joints using high-resolution peripheral quantitative computed tomography (HR-pQCT) was studied.
Methods: Cadaveric MCP were imaged at 7 flexion angles between 0 and 30 degrees. The variability in reproducibility for mean, minimum, and maximum joint space widths and volume measurements was calculated for increasing degrees of flexion.
Results: Root mean square coefficient of variance values were < 5% under 20 degrees of flexion for mean, maximum, and volumetric joint spaces. Values for minimum joint space width were optimized under 10 degrees of flexion.
Conclusion: MCP joint space measurements should be acquired at < 10 degrees of flexion in longitudinal studies.
|Item Type:||Refereed Article|
|Keywords:||high-resolution peripheral quantitative computed tomography, joint space narrowing, osteoarthritis, rheumatoid arthritis|
|Research Group:||Biomedical engineering|
|Research Field:||Biomechanical engineering|
|Objective Division:||Expanding Knowledge|
|Objective Group:||Expanding knowledge|
|Objective Field:||Expanding knowledge in engineering|
|UTAS Author:||Stok, KS (Dr Kathryn Stok)|
|Web of Science® Times Cited:||7|
|Deposited By:||Menzies Institute for Medical Research|
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