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Emerging role and characterization of immunometabolism: Relevance to HIV pathogenesis, serious non-AIDS events, and a cure
journal contribution
posted on 2023-05-20, 05:03 authored by Palmer, CS, Darren HenstridgeDarren Henstridge, Yu, D, Singh, A, Balderson, B, Duette, G, Cherry, CL, Anzinger, JJ, Ostrowski, M, Crowe, SMImmune cells cycle between a resting and an activated state. Their metabolism is tightly linked to their activation status and, consequently, functions. Ag recognition induces T lymphocyte activation and proliferation and acquisition of effector functions that require and depend on cellular metabolic reprogramming. Likewise, recognition of pathogen-associated molecular patterns by monocytes and macrophages induces changes in cellular metabolism. As obligate intracellular parasites, viruses manipulate the metabolism of infected cells to meet their structural and functional requirements. For example, HIV-induced changes in immune cell metabolism and redox state are associated with CD4+ T cell depletion, immune activation, and inflammation. In this review, we highlight how HIV modifies immunometabolism with potential implications for cure research and pathogenesis of comorbidities observed in HIV-infected patients, including those with virologic suppression. In addition, we highlight recently described key methods that can be applied to study the metabolic dysregulation of immune cells in disease states.
History
Publication title
Journal of ImmunologyVolume
196Issue
11Pagination
4437-4444ISSN
0022-1767Department/School
School of Health SciencesPublisher
Amer Assoc ImmunologistsPlace of publication
9650 Rockville Pike, Bethesda, USA, Md, 20814Rights statement
Copyright 2016 The American Association of Immunologists, Inc.Repository Status
- Restricted