Gascoyne, CR and Simpson Jr, S and Chen, J and van der Mei, I and Marck, CH, Modifiable factors associated with depression and anxiety in multiple sclerosis, Acta Neurologica Scandinavica pp. 1-8. ISSN 0001-6314 (2019) [Refereed Article]
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Available from 24 May 2020
Copyright 2019 John Wiley & Sons A/S.
Materials and Methods: Self-reported data from the Australian Multiple Sclerosis Longitudinal Study included the Hospital Anxiety and Depression Scale (HADS) and lifestyle measurements from 1500 participants. SNAP score (range 0-5) was the sum of non-smoking, sufficient fruit/vegetable intake, non-hazardous alcohol consumption, sufficient physical activity and healthy BMI. Analyses by log-binomial and linear regression were adjusted for confounding.
Results: Symptoms of depression and anxiety were prevalent in 27% and 40%, respectively; 20% had both. Mean SNAP score was 2.7/5; only 3% met all healthy lifestyle recommendations. Only 10% reported adequate fruit/vegetable intake, and 22% reported a combination of unhealthy BMI, inadequate physical activity and inadequate nutrition. A healthier SNAP score was associated with lower depression prevalence (adjusted prevalence ratio 0.83 [95% CI 0.75, 0.92] per unit increase) and depression severity (adjusted β-0.44 [95% CI -0.64, -0.24]), but not with anxiety.
Conclusions: Modifiable lifestyle factors are associated with lower frequency and severity of depression, but not anxiety, in Australian people with multiple sclerosis. The associations between a healthier SNAP score and lower depression are likely bi-directional. SNAP risk factor prevalence and co-occurrence, especially inadequate nutrition and low physical activity, were high among Australians with MS.
|Item Type:||Refereed Article|
|Keywords:||SNAP, anxiety, depression, health behaviours, lifestyle, multiple sclerosis|
|Research Division:||Medical and Health Sciences|
|Research Field:||Central Nervous System|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Nervous System and Disorders|
|UTAS Author:||Simpson Jr, S (Dr Steve Simpson JR)|
|UTAS Author:||Chen, J (Miss Jing Chen)|
|UTAS Author:||van der Mei, I (Associate Professor Ingrid van der Mei)|
|Deposited By:||Menzies Institute for Medical Research|
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