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Latitude continues to be significantly associated with the prevalence of multiple sclerosis: an updated meta-analysis

Citation

Simpson Jr, S and Wang, W and Otahal, P and Blizzard, L and van der Mei, IAF and Taylor, BV, Latitude continues to be significantly associated with the prevalence of multiple sclerosis: an updated meta-analysis, Journal of Neurology, Neurosurgery and Psychiatry, (June) pp. 1-8. ISSN 0022-3050 (2019) [Refereed Article]

Copyright Statement

Author(s) (or their employer(s)) 2019.

DOI: doi:10.1136/jnnp-2018-320189

Abstract

Objectives: Previous studies have demonstrated a strong latitudinal gradient in multiple sclerosis (MS) prevalence. Herein, we present a meta-analysis of the latitudinal gradient of MS prevalence including studies published since our 2011 review, seeking to assess the latitudinal gradient and whether it has changed since our previous analysis.

Methods: Studies published up to December 2018 were located via Embase, Web of Knowledge and PubMed, using standardised search terms; data were extracted from peer-reviewed studies and these studies added to those from our previous analysis. Where age-specific data were available, prevalence estimates were age-/sex-standardised to the 2009 European population. Prevalence estimates were adjusted for study prevalence year and ascertainment methods. The latitudinal association with MS prevalence was assessed by meta-regression.

Results: A total of 94 studies met inclusion criteria, yielding 230 new prevalence points and 880 altogether with those from the prior study. There was a significant positive gradient in time-corrected MS prevalence with increasing latitude (5.27/100 000 per degree latitude), attenuating slightly to 4.34/100 000 on age-standardisation, these associations persisting on adjustment for ascertainment method. Of note, the age-standardised gradient was consistently significantly enhanced from our previous study, regardless of whether it was as-measured, time-corrected or adjusted for ascertainment methods. Certain areas, such as the Scandinavian and Atlantic Coast/Central Europe regions, showed changes in MS prevalence gradient over time, but other regional gradients were similar.

Conclusions: This new meta-analysis confirms that MS prevalence is still strongly positively associated with increasing latitude and that the gradient is increasing, suggesting that potentially modifiable environmental factors, such as sun exposure, are still strongly associated with MS risk.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
UTAS Author:Simpson Jr, S (Dr Steve Simpson JR)
UTAS Author:Otahal, P (Mr Petr Otahal)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:van der Mei, IAF (Associate Professor Ingrid van der Mei)
UTAS Author:Taylor, BV (Professor Bruce Taylor)
ID Code:133413
Year Published:2019
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-06-27
Last Modified:2019-08-23
Downloads:0

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