eCite Digital Repository

Cytokines expression levels from tissue, plasma or serum as promising clinical biomarkers in adenocarcinoma of the prostate: A systematic review of recent findings


Singh, J and Sohal, SS and Lim, A and Duncan, H and Thachil, T and De Ieso, P, Cytokines expression levels from tissue, plasma or serum as promising clinical biomarkers in adenocarcinoma of the prostate: A systematic review of recent findings, Annals of Translational Medicine, 7, (11) pp. 245. ISSN 2305-5839 (2019) [Refereed Article]

Restricted - Request a copy

Copyright Statement

Copyright 2019 Annals of Translational Medicine

DOI: doi:10.21037/atm.2019.05.31


Prostate cancer (PC) is a common cancer (excluding non-melanoma skin cancer) in men in many parts of the world, although incidence and mortality rates vary significantly by population. In current medical practice, prognostic markers for PC include the presenting serum prostate-specific antigen (PSA) level, tumour Gleason score (GS) and clinical tumour stage. However, existing pre-treatment factors cannot be used to predict acute radiotherapy (RT)-induced toxicity. Therefore, new protein biomarkers are required in RT oncology to improve decision-making, treatment and therapy monitoring for PC patients. The aim of this systematic review is to the update potential research to address the difference in cytokine expression and their association with RT-induced toxicity and clinical outcomes. Studies were collected after searching three electronic databases: PubMed, Medline, and Google Scholar. An additional search was carried out through cross-check on a bibliography of selected articles. After the selection process made by two of the authors, 19 articles met the inclusion criteria and were included in the systematic review. Results from previous studies identified elevated levels of cytokines have been reported in several types of cancers and have sometimes correlated with disease progression or prognosis. Elevated levels of cytokine were noticed after immediate exposure to RT and their association with RT-induced acute/late toxicity of PC patients. Moreover, above studies also identified overexpression of cytokines on tumour biopsies and correlation with shortening cancer-specific survival and biochemical recurrence. Thus, altered levels of cytokine might be predictive biomarkers for RT-induced and clinical outcomes of PC patients.

Item Details

Item Type:Refereed Article
Keywords:radical prostatectomy (RP), radiotherapy (RT), incidence/mortality, RT-induced toxicity, biochemical recurrence, cancer-specific survival, adenocarcinoma, cancer, cytokines, biomarkers, prostate
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:133390
Year Published:2019
Web of Science® Times Cited:9
Deposited By:Health Sciences
Deposited On:2019-06-25
Last Modified:2020-06-12

Repository Staff Only: item control page