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APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding

Citation

Czeczor, JK and Genders, AJ and Aston-Mourney, K and Connor, T and Hall, LG and Hasebe, K and Ellis, M and De Jong, KA and Henstridge, DC and Meikle, PJ and Febbraio, MA and Walder, K and McGee, SL, APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding, Journal of Endocrinology, 237, (3) pp. 311-322. ISSN 0022-0795 (2018) [Refereed Article]

Copyright Statement

Copyright 2018 Society for Endocrinology

DOI: doi:10.1530/JOE-18-0051

Abstract

The amyloid precursor protein (APP) generates a number of peptides when processed through different cleavage mechanisms, including the amyloid beta peptide that is implicated in the development of Alzheimer’s disease. It is well established that APP via its cleaved peptides regulates aspects of neuronal metabolism. Emerging evidence suggests that amyloidogenic processing of APP can lead to altered systemic metabolism, similar to that observed in metabolic disease states. In the present study, we investigated the effect of APP deficiency on obesity-induced alterations in systemic metabolism. Compared with WT littermates, APP-deficient mice were resistant to diet-induced obesity, which was linked to higher energy expenditure and lipid oxidation throughout the dark phase and was associated with increased spontaneous physical activity. Consistent with this lean phenotype, APP-deficient mice fed a high-fat diet (HFD) had normal insulin tolerance. However, despite normal insulin action, these mice were glucose intolerant, similar to WT mice fed a HFD. This was associated with reduced plasma insulin in the early phase of the glucose tolerance test. Analysis of the pancreas showed that APP was required to maintain normal islet and β-cell mass under high fat feeding conditions. These studies show that, in addition to regulating aspects of neuronal metabolism, APP is an important regulator of whole body energy expenditure and glucose homeostasis under high fat feeding conditions.

Item Details

Item Type:Refereed Article
Keywords:amyloid precursor protein, energy expenditure glucose metabolism, insulin secretion, obesity, amyloid precursor protein, cyclic AMP dependent protein kinase, cyclic AMP responsive element binding protein, genomic DNA, glucose, insulin, lipid, male
Research Division:Biological Sciences
Research Group:Biochemistry and cell biology
Research Field:Cell metabolism
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Henstridge, DC (Mr Darren Henstridge)
ID Code:133380
Year Published:2018
Web of Science® Times Cited:6
Deposited By:Health Sciences
Deposited On:2019-06-24
Last Modified:2019-07-23
Downloads:0

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