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Early life exposure to coal mine fire smoke emissions and altered lung function in young children

Citation

Shao, J and Zosky, GR and Hall, GL and Wheeler, AJ and Dharmage, S and Melody, S and Dalton, M and Foong, RE and O'Sullivan, T and Williamson, GJ and Chappell, K and Abramson, MJ and Johnston, FH, Early life exposure to coal mine fire smoke emissions and altered lung function in young children, Respirology pp. 1-8. ISSN 1323-7799 (2019) [Refereed Article]

Copyright Statement

© 2019 Asian Pacific Society of Respirology

DOI: doi:10.1111/resp.13617

Abstract

Background and objective: Long‐term respiratory risks following exposure to relatively short periods of poor air quality early in life are unknown. We aimed to evaluate the association between exposure to a 6‐week episode of air pollution from a coal mine fire in children aged <2 years, and their lung function 3 years after the fire.

Methods: We conducted a prospective cohort study. Individual exposure to 24‐h average and peak concentrations of particulate matter with an aerodynamic diameter < 2.5 μm in diameter (PM2.5) during the fire were estimated using dispersion and chemical transport modelling. Lung function was measured using the forced oscillation technique (FOT), generating standardized Z‐scores for resistance and reactance at a frequency of 5 Hz (Rrs5 and Xrs5), and area under the reactance curve (AX). We used linear regression models to assess the associations between PM2.5 exposure and lung function, adjusted for potential confounders.

Results: Of the 203 infants originally recruited, 84 aged 4.3 ± 0.5 years completed FOT testing. Median (interquartile range, IQR) for average and peak PM2.5 were 7.9 (6.8-16.8) and 103.4 (60.6-150.7) μg/m3, respectively. The mean ± SD Z‐scores for Rrs5, Xrs5 and AX were 0.56 ± 0.80, -0.76 ± 0.88 and 0.72 ± 0.92, respectively. After adjustment for potential confounders including maternal smoking during pregnancy, a 10 μg/m3 increase in average PM2.5 was significantly associated with worsening AX (β‐coefficient: 0.260; 95% CI: 0.019, 0.502), while the association between a 100‐μg/m3 increase in peak PM2.5 and AX was borderline (0.166; 95% CI: -0.002, 0.334).

Conclusion: Infant exposure to coal mine fire emissions could be associated with long‐term impairment of lung reactance.

Item Details

Item Type:Refereed Article
Keywords:long-term effects, outdoor smoke, particulate matter, preschool children, respiratory function tests, coal
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
UTAS Author:Shao, J (Miss Jingyi Shao)
UTAS Author:Zosky, GR (Professor Graeme Zosky)
UTAS Author:Wheeler, AJ (Dr Amanda Wheeler)
UTAS Author:Melody, S (Dr Shannon Melody)
UTAS Author:Dalton, M (Ms Marita Dalton)
UTAS Author:O'Sullivan, T (Miss Tierney O'Sullivan)
UTAS Author:Williamson, GJ (Dr Grant Williamson)
UTAS Author:Chappell, K (Ms Katherine Chappell)
UTAS Author:Johnston, FH (Associate Professor Fay Johnston)
ID Code:133346
Year Published:2019
Deposited By:Plant Science
Deposited On:2019-06-24
Last Modified:2019-10-29
Downloads:0

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