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The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells
Citation
Man, K and Miasari, M and Shi, W and Xin, A and Henstridge, DC and Preston, S and Pellegrini, M and Belz, GT and Smyth, GK and Febbraio, MA and Nutt, SL and Kallies, A, The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells, Nature Immunology, 14, (11) pp. 1155-1165. ISSN 1529-2908 (2013) [Refereed Article]
Copyright Statement
Copyright 2013 Springer Nature
DOI: doi:10.1038/ni.2710
Abstract
During immune responses, T cells are subject to clonal competition, which leads to the predominant expansion of high-affinity clones; however, there is little understanding of how this process is controlled. We found here that the transcription factor IRF4 was induced in a manner dependent on affinity for the T cell antigen receptor (TCR) and acted as a dose-dependent regulator of the metabolic function of activated T cells. IRF4 regulated the expression of key molecules required for the aerobic glycolysis of effector T cells and was essential for the clonal expansion and maintenance of effector function of antigen-specific CD8+ T cells. Thus, IRF4 is an indispensable molecular 'rheostat' that 'translates' TCR affinity into the appropriate transcriptional programs that link metabolic function with the clonal selection and effector differentiation of T cells.
Item Details
Item Type: | Refereed Article |
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Keywords: | beta actin, CD8 antigen, Hermes antigen, interferon regulatory factor 4, interleukin 2 receptor alpha, T lymphocyte receptor, animal cell, antigen specificity, article, binding affinity, CD8+ T lymphocyte, cell expansion, cell metabolism, glycolysis |
Research Division: | Biological Sciences |
Research Group: | Biochemistry and cell biology |
Research Field: | Signal transduction |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Henstridge, DC (Dr Darren Henstridge) |
ID Code: | 133345 |
Year Published: | 2013 |
Web of Science® Times Cited: | 253 |
Deposited By: | Health Sciences |
Deposited On: | 2019-06-24 |
Last Modified: | 2019-07-23 |
Downloads: | 0 |
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