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ABCA1 expression in humans is associated with physical activity and alcohol consumption


Hoang, A and Tefft, C and Duffy, SJ and Formosa, M and Henstridge, DC and Kingwell, BA and Sviridov, D, ABCA1 expression in humans is associated with physical activity and alcohol consumption, Atherosclerosis, 197, (1) pp. 197-203. ISSN 0021-9150 (2008) [Refereed Article]

Copyright Statement

2007 Elsevier Ireland Ltd. All rights reserved.

DOI: doi:10.1016/j.atherosclerosis.2007.03.017


Genetic variation in ABCA1 significantly affects HDL levels and atherosclerotic risk. The aim of this study was to examine lifestyle factors influencing ABCA1 expression in human leukocytes and skeletal muscle. A fasting venous blood sample and a vastus lateralis muscle biopsy were taken from 30 volunteers (53 1 years; mean S.E.M.). Levels of ABCA1 mRNA were measured in blood leukocytes and muscle biopsies. Plasma-induced cholesterol efflux from THP-1 human macrophages as well as plasma lipids and lipid-related parameters were also measured. The amount of alcohol consumed per week correlated strongly with both muscle ABCA1 expression (r2 = +0.37, p < 0.001) and cholesterol efflux (r2 = +0.41, p < 0.001). Higher levels of physical exercise were associated with higher leukocyte ABCA1 expression (p < 0.005), and higher concentrations of plasma apoA-I (p < 0.05) and preβ1-HDL (p < 0.001). All these relationships were independent of diabetic status on multivariate analysis. ABCA1 expression in leukocytes and skeletal muscle was not related, suggesting different regulatory mechanisms. In conclusion, ABCA1 expression in human leukocytes and muscle is associated with physical activity and alcohol consumption, respectively.

Item Details

Item Type:Refereed Article
Keywords:atherosclerosis, HDL, lipoproteins, reverse cholesterol transport, risk factors, ABC transporter A1, apolipoprotein A1, high density lipoprotein, adult, alcohol consumption, article, cholesterol transport, clinical article, controlled study, human
Research Division:Biological Sciences
Research Group:Biochemistry and cell biology
Research Field:Cell metabolism
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Henstridge, DC (Mr Darren Henstridge)
ID Code:133320
Year Published:2008
Web of Science® Times Cited:30
Deposited By:Health Sciences
Deposited On:2019-06-24
Last Modified:2019-08-08

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