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Hormonal contraception and the brain: Examining cognition and psychiatric disorders


Laird, S and Ney, LJ and Felmingham, KL and Gogos, A, Hormonal contraception and the brain: Examining cognition and psychiatric disorders, Current Psychiatry Research and Reviews, 15 pp. 1-16. ISSN 1573-4005 (2019) [Refereed Article]

Copyright Statement

2019 Bentham Science Publishers

DOI: doi:10.2174/1573400515666190521113841


Background: The combined oral contraceptive pill (OC), containing synthetic estrogens and progestins, is used by millions of women worldwide, yet little is known about its effects on cognition or on psychiatric disorders. The progestin component of OCs determines their androgenicity, i.e. whether the OC has androgen binding components with masculinising effects or antiandrogenic components with feminising effects.

Objective: The present review discusses the literature surrounding OC use and cognition in healthy women. Given the important role that sex hormones play in psychiatric disorders, we also consider the influence of OCs on symptoms of schizophrenia, post-traumatic stress disorder, depression, bipolar disorder, anxiety disorders and indirectly, sleep quality.

Results: Research has shown that while there are no differences between OC users and non-users, androgenic OCs enhance visuospatial ability and anti-androgenic OCs enhance verbal fluency. Little is known about OCs effects on other cognitive domains, such as memory and executive function. There is little research examining OC use in schizophrenia, post-traumatic stress disorder, bipolar disorder and anxiety disorders. There is some evidence that OC use is associated with depression, however the exact causality of this association remains to be verified.

Conclusion: We maintain that future studies need to address several methodological limitations, such as separating OCs based on androgenicity to avoid the masking effects that occur when various OCs are considered as one group. As this review highlights several significant effects of OC use on the brain, the implications of OC use needs to be considered in future research.

Item Details

Item Type:Refereed Article
Keywords:women, oral contraceptive pill, naturally-cycling, androgenicity, anxiety, depression, PTSD, schizophrenia, sex differences, sex hormones, posttraumatic stress disorder, cognition, contraceptives,anxiety disorders
Research Division:Psychology
Research Group:Biological psychology
Research Field:Behavioural neuroscience
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Ney, LJ (Mr Luke Ney)
ID Code:133291
Year Published:2019
Web of Science® Times Cited:6
Deposited By:Psychology
Deposited On:2019-06-21
Last Modified:2020-03-11
Downloads:1 View Download Statistics

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