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Lesson of the month 2: Transient reversible amnesia in multiple sclerosis


Shanmugarajah, PD and Alty, J and Lily, O and Ford, HL, Lesson of the month 2: Transient reversible amnesia in multiple sclerosis, Clinical Medicine, 17, (1) pp. 88-90. ISSN 1470-2118 (2017) [Contribution to Refereed Journal]

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DOI: doi:10.7861/clinmedicine.17-1-88


Transient amnestic syndromes are fascinating clinical entities and there are several subtypes. Transient global amnesia (TGA) is characterised by sudden onset of anterograde amnesia with repetitive questioning, lasting less than 24 hours. The pathophysiology of TGA involves the medial temporal lobes and hippocampi. Episodes of TGA are thought to involve venous congestion with Valsalvalike activities, vascular or migrainous mechanisms. In contrast, transient epileptic amnesia manifests as brief and frequent episodes of amnesia due to seizure activity in the temporal lobes. Transient memory disturbances can also be caused by transient ischaemic attack. We describe the first reported case of transient reversible amnesia directly attributable to acute demyelination. This case reminds us that multiple sclerosis relapses may present with acute cognitive impairment rather than the more classical physical symptoms. This is an important learning point in terms of appropriate management and eligibility for disease-modifying drugs.

Item Details

Item Type:Contribution to Refereed Journal
Keywords:anterograde amnesia , demyelinating disorders , multiple sclerosis , temporal lobe,MS, neuropsychiatrics, diagnosis
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Alty, J (Associate Professor Jane Alty)
ID Code:133242
Year Published:2017
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2019-06-19
Last Modified:2019-06-20

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