eCite Digital Repository

A new evolutionary algorithm-based home monitoring device for Parkinson's dyskinesia

Citation

Lones, MA and Alty, JE and Cosgrove, J and Duggan-Carter, P and Jamieson, S and Naylor, RF and Turner, AJ and Smith, SL, A new evolutionary algorithm-based home monitoring device for Parkinson's dyskinesia, Journal of Medical Systems, 41, (176) pp. 1-8. ISSN 0148-5598 (2017) [Refereed Article]


Preview
PDF
1Mb
  

Copyright Statement

Copyright 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1007/s10916-017-0811-7

Abstract

Parkinsonís disease (PD) is a neurodegenerative movement disorder. Although there is no cure, symptomatic treatments are available and can significantly improve quality of life. The motor, or movement, features of PD are caused by reduced production of the neurotransmitter dopamine. Dopamine deficiency is most often treated using dopamine replacement therapy. However, this therapy can itself lead to further motor abnormalities referred to as dyskinesia. Dyskinesia consists of involuntary jerking movements and muscle spasms, which can often be violent. To minimise dyskinesia, it is necessary to accurately titrate the amount of medication given and monitor a patientís movements. In this paper, we describe a new home monitoring device that allows dyskinesia to be measured as a patient goes about their daily activities, providing information that can assist clinicians when making changes to medication regimens. The device uses a predictive model of dyskinesia that was trained by an evolutionary algorithm, and achieves AUC>0.9 when discriminating clinically significant dyskinesia.

Item Details

Item Type:Refereed Article
Keywords:neurology, neurodegenerative, evolutionary algorithms, Parkinson's
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Geriatrics and Gerontology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
UTAS Author:Alty, JE (Dr Jane Alty)
ID Code:133240
Year Published:2017
Web of Science® Times Cited:2
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2019-06-19
Last Modified:2019-10-18
Downloads:3 View Download Statistics

Repository Staff Only: item control page