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Multiple plasmacytoma with multiple neurological presentations: A difficult case


Smith, N and Kimberger, K and Parrish, C and Currie, S and Butterworth, S and Alty, JE, Multiple plasmacytoma with multiple neurological presentations: A difficult case, Practical Neurology, 19, (6) pp. 511-517. ISSN 1474-7758 (2019) [Contribution to Refereed Journal]

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DOI: doi:10.1136/practneurol-2019-002205


Multiple myeloma is a haematological malignancy with clonal plasma cell proliferation and production of monoclonal immunoglobulins. Its neurological complications are relatively common, caused by both the disease and the treatment. Neurologists should therefore be familiar with its neurological manifestations and complications. We describe a 40-year-old woman who presented with lower cranial neuropathies mimicking variant Guillain-Barré syndrome, with normal brain and spinal cord imaging and cerebrospinal fluid (CSF) albuminocytological dissociation, and subsequently diagnosed with IgD myeloma. She relapsed repeatedly with differing neurological presentations: numb chin syndrome and twice with impaired vision, first from cerebral venous sinus thrombosis and later from leptomeningeal infiltration of the optic chiasm. We discuss the neurological complications of myeloma, emphasising the need to consider it in a wide variety of neurological presentations and repeatedly to reassess its associated neurological diagnoses. We also highlight the complexity of myeloma treatment.

Item Details

Item Type:Contribution to Refereed Journal
Keywords:myeloma, neurology
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Alty, JE (Associate Professor Jane Alty)
ID Code:133232
Year Published:2019
Web of Science® Times Cited:3
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2019-06-19
Last Modified:2022-11-05

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