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Quantitative evaluation of mechanical properties in tissue-engineered auricular cartilage

Citation

Nimeskern, L and van Osch, GJVM and Muller, R and Stok, KS, Quantitative evaluation of mechanical properties in tissue-engineered auricular cartilage, Tissue Engineering: Part B, 20, (1) pp. 17-27. ISSN 1937-3368 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Mary Ann Liebert, Inc.

DOI: doi:10.1089/ten.teb.2013.0117

Abstract

Tissue-engineering (TE) efforts for ear reconstruction often fail due to mechanical incompetency. It is therefore key for successful auricular cartilage (AUC) TE to ensure functional competency, that is, to mimic the mechanical properties of the native ear tissue. A review of past attempts to engineer AUC shows unsatisfactory functional outcomes with various cell-seeded biodegradable polymeric scaffolds in immunocompetent animal models. However, promising improvements to construct stability were reported with either mechanically reinforced scaffolds or novel two-stage implantation techniques. Nonetheless, quantitative mechanical evaluation of the constructs is usually overlooked, and such an evaluation of TE constructs alongside a benchmark of native AUC would allow real-time monitoring and improve functional outcomes of auricular TE strategies. Although quantitative mechanical evaluation techniques are readily available for cartilage, these techniques are designed to characterize the main functional components of hyaline and fibrous cartilage such as the collagen matrix or the glycosaminoglycan network, but they overlook the functional role of elastin, which is a major constituent of AUC. Hence, for monitoring AUC TE, novel evaluation techniques need to be designed. These should include a characterization of the specific composition and architecture of AUC, as well as mechanical evaluation of all functional components. Therefore, this article reviews the existing literature on AUC TE as well as cartilage mechanical evaluation and proposes recommendations for designing a mechanical evaluation protocol specific for AUC, and establishing a benchmark for native AUC to be used for quantitative evaluation of TE AUC.

Item Details

Item Type:Refereed Article
Research Division:Engineering
Research Group:Biomedical engineering
Research Field:Biomechanical engineering
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in engineering
UTAS Author:Stok, KS (Dr Kathryn Stok)
ID Code:133195
Year Published:2014
Web of Science® Times Cited:18
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-06-18
Last Modified:2019-07-23
Downloads:0

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