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N-of-1 trials for closed-loop deep brain stimulation devices

Citation

Stevens, I and Gilbert, F, N-of-1 trials for closed-loop deep brain stimulation devices, Ethics & Human Research, 42, (2) pp. 28-33. ISSN 2578-2355 (2020) [Refereed Article]


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Copyright Statement

© 2020 by The Hastings Center. All rights reserved. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This is the peer reviewed version of the following article: Stevens, I and Gilbert, F, N-of-1 trials for closed-loop deep brain stimulation devices, Ethics & Human Research, 42, (2) pp. 28-33. ISSN 2578-2355 (2020), which has been published in final form at:

DOI: doi:10.1002/eahr.500045

Abstract

Closed‐loop deep brain stimulation (DBS) devices hold great promise for treating various neurological and psychiatric conditions. Yet while these algorithmic‐based devices provide personalized treatment to each patient, they also present uniquely individualized risks of physiological and psychological harms. These experimental devices are typically tested in randomized controlled trials, which may not be the optimum approach to identifying and assessing phenomenological harms they pose to patients. In this article, we contend that an N‐of‐1 trial design—which is being used ever more frequently to realize the goals of individualized, precision medicine—could provide beneficial phenomenological data about the potential risks of harm to properly inform the use of closed‐loop DBS devices. Data from N‐of‐1 trials may provide patients, as well as their families and other caregivers, with better information on which to base informed choices about pursuing this type of treatment option.

Item Details

Item Type:Refereed Article
Keywords:brain-computer interfaces, N-of-1, ethics
Research Division:Philosophy and Religious Studies
Research Group:Applied ethics
Research Field:Ethical use of new technology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in philosophy and religious studies
UTAS Author:Gilbert, F (Dr Frederic Gilbert)
ID Code:133172
Year Published:2020
Funding Support:Australian Research Council (DE150101390)
Deposited By:Office of the School of Humanities
Deposited On:2019-06-16
Last Modified:2021-02-24
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