Laitinen, TT and Vahtera, J and Pahkala, K and Magnussen, CG and Nuotio, J and Hutri-Kahonen, N and Kivimaki, M and Lehtimaki, T and Jokinen, E and Laitinen, T and Tossavainen, P and Pentti, J and Viikari, JSA and Juonala, M and Raitakari, OT, Childhood socioeconomic disadvantage and risk of fatty liver in adulthood: the Cardiovascular Risk in Young Finns Study, Hepatology pp. 1-23. ISSN 0270-9139 (2019) [Refereed Article]
Fatty liver is a preventable cause of liver failure, but early risk factors for adulthood fatty liver are poorly understood. We examined the association of childhood socioeconomic disadvantage with adulthood fatty liver and tested adulthood risk factors of fatty liver as possible mediators of this link. The study population comprised 2,042 participants aged 3-18 years at baseline (1980) from the longitudinal Cardiovascular Risk in Young Finns Study. Follow-up with repeated clinical examinations was 31 years. Childhood socioeconomic disadvantage was assessed using data from parents' socioeconomic position and socioeconomic circumstances in participants' residential neighborhoods, categorized as high versus low socioeconomic disadvantage. Fatty liver was determined by ultrasound during the last follow up (2011) at ages 34-49 years. Childhood and adulthood risk factors, including metabolic biomarkers and life-style variables, were assessed in clinical examinations. 18.9% of the participants had fatty liver in adulthood. High childhood socioeconomic disadvantage was associated with an increased risk of fatty liver (risk ratio[95% confidence interval] 1.42[1.18-1.70],P=0.0002). This association was robust to adjustment for age, sex, and childhood risk factors of fatty liver, including high body mass index, elevated insulin, and low birth weight (1.33[1.09-1.62],P=0.005). High childhood socioeconomic disadvantage was also associated with the development of risk factors of fatty liver in adulthood. Adulthood risk factors linking childhood socioeconomic disadvantage with fatty liver included waist circumference (proportion mediated of the total effect of childhood socioeconomic disadvantage 45%), body mass index (40%), systolic blood pressure (29%), insulin (20%), physical activity (15%), triglycerides (14%), and red meat consumption (7%).
Conclusion: Childhood socioeconomic disadvantage was associated with multiple risk factors of fatty liver and increased likelihood of fatty liver in adulthood.
|Item Type:||Refereed Article|
|Keywords:||hepatic steatosis, longitudinal study, population study, risk factors, socioeconomic status|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|UTAS Author:||Magnussen, CG (Dr Costan Magnussen)|
|Deposited By:||Menzies Institute for Medical Research|
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